The opposing transcriptional functions of Sin3a and c-Myc are required to maintain tissue homeostasis

How the proto-oncogene c-Myc balances the processes of stem-cell self-renewal, proliferation and differentiation in adult tissues is largely unknown. We explored c-Myc’s transcriptional roles at the epidermal differentiation complex, a locus essential for skin maturation. Binding of c-Myc can simult...

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Veröffentlicht in:	Nature cell biology 2011-12, Vol.13 (12), p.1395-1405
Hauptverfasser:	Nascimento, Elisabete M., Cox, Claire L., MacArthur, Stewart, Hussain, Shobbir, Trotter, Matthew, Blanco, Sandra, Suraj, Menon, Nichols, Jennifer, Kübler, Bernd, Benitah, Salvador Aznar, Hendrich, Brian, Odom, Duncan T., Frye, Michaela
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/572 631/553/2711 631/80 Animals Biomedical and Life Sciences Cancer Cancer Research Cell Biology Cell growth Developmental Biology Epidermal Cells Epidermis - physiology Feedback, Physiological - physiology Female Genetic transcription Homeostasis Homeostasis - genetics Keratinocytes - cytology Keratinocytes - physiology Kruppel-Like Factor 4 Life Sciences Male Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Primary Cell Culture Proto-Oncogene Proteins c-myc - antagonists & inhibitors Proto-Oncogene Proteins c-myc - genetics Repressor Proteins - genetics Repressor Proteins - physiology Research parks Sin3 Histone Deacetylase and Corepressor Complex Stem Cells Tissues Transcription, Genetic - physiology
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