Cell death and infection: a double-edged sword for host and pathogen survival
Host cell death is an intrinsic immune defense mechanism in response to microbial infection. However, bacterial pathogens use many strategies to manipulate the host cell death and survival pathways to enhance their replication and survival. This manipulation is quite intricate, with pathogens often...
Gespeichert in:
| Veröffentlicht in: | The Journal of cell biology 2011-12, Vol.195 (6), p.931-942 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 942 |
|---|---|
| container_issue | 6 |
| container_start_page | 931 |
| container_title | The Journal of cell biology |
| container_volume | 195 |
| creator | Ashida, Hiroshi Mimuro, Hitomi Ogawa, Michinaga Kobayashi, Taira Sanada, Takahito Kim, Minsoo Sasakawa, Chihiro |
| description | Host cell death is an intrinsic immune defense mechanism in response to microbial infection. However, bacterial pathogens use many strategies to manipulate the host cell death and survival pathways to enhance their replication and survival. This manipulation is quite intricate, with pathogens often suppressing cell death to allow replication and then promoting it for dissemination. Frequently, these effects are exerted through modulation of the mitochondrial pro-death, NF-κB-dependent pro-survival, and inflammasome-dependent host cell death pathways during infection. Understanding the molecular details by which bacterial pathogens manipulate cell death pathways will provide insight into new therapeutic approaches to control infection. |
| doi_str_mv | 10.1083/jcb.201108081 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3241725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2537660121</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4381-7522598d3e82275f9b7833126fc9d6349704dd817df0f20a1f7f689e223548f03</originalsourceid><addsrcrecordid>eNpdkUFvEzEQhS0EomnhyBVZXDhtmRl7Y5sDEoqgIBX1Us6Ws7aTjTbrYO8G8e9raImgpxlpvnmaeY-xVwiXCFq823XrSwKsPWh8whbYSmg0SnjKFgCEjWmpPWPnpewAQCopnrMzIiShBSzYt1UYBu6Dm7bcjZ73Ywzd1KfxPXfcp3k9hCb4TfC8_EzZ85gy36Yy_YEPdSttwsjLnI_90Q0v2LPohhJePtQL9v3zp9vVl-b65urr6uN100mhsVEtUWu0F0ETqTaatdJCIC1jZ_xSSKNAeq9R-QiRwGFUcalNIBKt1BHEBftwr3uY1_vguzBO2Q32kPu9y79scr39fzL2W7tJRytIoqK2Crx9EMjpxxzKZPd96aoVbgxpLtYgGlldxUq-eUTu0pzH-l2FwChBKCrU3ENdTqXkEE-nINjfMdkakz3FVPnX_95_ov_mIu4AHeOMIA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>910973213</pqid></control><display><type>article</type><title>Cell death and infection: a double-edged sword for host and pathogen survival</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Ashida, Hiroshi ; Mimuro, Hitomi ; Ogawa, Michinaga ; Kobayashi, Taira ; Sanada, Takahito ; Kim, Minsoo ; Sasakawa, Chihiro</creator><creatorcontrib>Ashida, Hiroshi ; Mimuro, Hitomi ; Ogawa, Michinaga ; Kobayashi, Taira ; Sanada, Takahito ; Kim, Minsoo ; Sasakawa, Chihiro</creatorcontrib><description>Host cell death is an intrinsic immune defense mechanism in response to microbial infection. However, bacterial pathogens use many strategies to manipulate the host cell death and survival pathways to enhance their replication and survival. This manipulation is quite intricate, with pathogens often suppressing cell death to allow replication and then promoting it for dissemination. Frequently, these effects are exerted through modulation of the mitochondrial pro-death, NF-κB-dependent pro-survival, and inflammasome-dependent host cell death pathways during infection. Understanding the molecular details by which bacterial pathogens manipulate cell death pathways will provide insight into new therapeutic approaches to control infection.</description><identifier>ISSN: 0021-9525</identifier><identifier>EISSN: 1540-8140</identifier><identifier>DOI: 10.1083/jcb.201108081</identifier><identifier>PMID: 22123830</identifier><identifier>CODEN: JCLBA3</identifier><language>eng</language><publisher>United States: Rockefeller University Press</publisher><subject>Animals ; Apoptosis ; Apoptosis - immunology ; Bacterial Infections - immunology ; Bacterial Infections - pathology ; Host-Pathogen Interactions - immunology ; Humans ; Infections ; Inflammasomes - immunology ; Mice ; Mitochondria ; Mitochondria - immunology ; Necrosis ; Pathogens ; Phagocytes - immunology ; Phagocytes - microbiology ; Reviews ; Signal transduction</subject><ispartof>The Journal of cell biology, 2011-12, Vol.195 (6), p.931-942</ispartof><rights>Copyright Rockefeller University Press Dec 12, 2011</rights><rights>2011 Ashida et al. 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4381-7522598d3e82275f9b7833126fc9d6349704dd817df0f20a1f7f689e223548f03</citedby><cites>FETCH-LOGICAL-c4381-7522598d3e82275f9b7833126fc9d6349704dd817df0f20a1f7f689e223548f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22123830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ashida, Hiroshi</creatorcontrib><creatorcontrib>Mimuro, Hitomi</creatorcontrib><creatorcontrib>Ogawa, Michinaga</creatorcontrib><creatorcontrib>Kobayashi, Taira</creatorcontrib><creatorcontrib>Sanada, Takahito</creatorcontrib><creatorcontrib>Kim, Minsoo</creatorcontrib><creatorcontrib>Sasakawa, Chihiro</creatorcontrib><title>Cell death and infection: a double-edged sword for host and pathogen survival</title><title>The Journal of cell biology</title><addtitle>J Cell Biol</addtitle><description>Host cell death is an intrinsic immune defense mechanism in response to microbial infection. However, bacterial pathogens use many strategies to manipulate the host cell death and survival pathways to enhance their replication and survival. This manipulation is quite intricate, with pathogens often suppressing cell death to allow replication and then promoting it for dissemination. Frequently, these effects are exerted through modulation of the mitochondrial pro-death, NF-κB-dependent pro-survival, and inflammasome-dependent host cell death pathways during infection. Understanding the molecular details by which bacterial pathogens manipulate cell death pathways will provide insight into new therapeutic approaches to control infection.</description><subject>Animals</subject><subject>Apoptosis</subject><subject>Apoptosis - immunology</subject><subject>Bacterial Infections - immunology</subject><subject>Bacterial Infections - pathology</subject><subject>Host-Pathogen Interactions - immunology</subject><subject>Humans</subject><subject>Infections</subject><subject>Inflammasomes - immunology</subject><subject>Mice</subject><subject>Mitochondria</subject><subject>Mitochondria - immunology</subject><subject>Necrosis</subject><subject>Pathogens</subject><subject>Phagocytes - immunology</subject><subject>Phagocytes - microbiology</subject><subject>Reviews</subject><subject>Signal transduction</subject><issn>0021-9525</issn><issn>1540-8140</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUFvEzEQhS0EomnhyBVZXDhtmRl7Y5sDEoqgIBX1Us6Ws7aTjTbrYO8G8e9raImgpxlpvnmaeY-xVwiXCFq823XrSwKsPWh8whbYSmg0SnjKFgCEjWmpPWPnpewAQCopnrMzIiShBSzYt1UYBu6Dm7bcjZ73Ywzd1KfxPXfcp3k9hCb4TfC8_EzZ85gy36Yy_YEPdSttwsjLnI_90Q0v2LPohhJePtQL9v3zp9vVl-b65urr6uN100mhsVEtUWu0F0ETqTaatdJCIC1jZ_xSSKNAeq9R-QiRwGFUcalNIBKt1BHEBftwr3uY1_vguzBO2Q32kPu9y79scr39fzL2W7tJRytIoqK2Crx9EMjpxxzKZPd96aoVbgxpLtYgGlldxUq-eUTu0pzH-l2FwChBKCrU3ENdTqXkEE-nINjfMdkakz3FVPnX_95_ov_mIu4AHeOMIA</recordid><startdate>20111212</startdate><enddate>20111212</enddate><creator>Ashida, Hiroshi</creator><creator>Mimuro, Hitomi</creator><creator>Ogawa, Michinaga</creator><creator>Kobayashi, Taira</creator><creator>Sanada, Takahito</creator><creator>Kim, Minsoo</creator><creator>Sasakawa, Chihiro</creator><general>Rockefeller University Press</general><general>The Rockefeller University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111212</creationdate><title>Cell death and infection: a double-edged sword for host and pathogen survival</title><author>Ashida, Hiroshi ; Mimuro, Hitomi ; Ogawa, Michinaga ; Kobayashi, Taira ; Sanada, Takahito ; Kim, Minsoo ; Sasakawa, Chihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4381-7522598d3e82275f9b7833126fc9d6349704dd817df0f20a1f7f689e223548f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Apoptosis</topic><topic>Apoptosis - immunology</topic><topic>Bacterial Infections - immunology</topic><topic>Bacterial Infections - pathology</topic><topic>Host-Pathogen Interactions - immunology</topic><topic>Humans</topic><topic>Infections</topic><topic>Inflammasomes - immunology</topic><topic>Mice</topic><topic>Mitochondria</topic><topic>Mitochondria - immunology</topic><topic>Necrosis</topic><topic>Pathogens</topic><topic>Phagocytes - immunology</topic><topic>Phagocytes - microbiology</topic><topic>Reviews</topic><topic>Signal transduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ashida, Hiroshi</creatorcontrib><creatorcontrib>Mimuro, Hitomi</creatorcontrib><creatorcontrib>Ogawa, Michinaga</creatorcontrib><creatorcontrib>Kobayashi, Taira</creatorcontrib><creatorcontrib>Sanada, Takahito</creatorcontrib><creatorcontrib>Kim, Minsoo</creatorcontrib><creatorcontrib>Sasakawa, Chihiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of cell biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ashida, Hiroshi</au><au>Mimuro, Hitomi</au><au>Ogawa, Michinaga</au><au>Kobayashi, Taira</au><au>Sanada, Takahito</au><au>Kim, Minsoo</au><au>Sasakawa, Chihiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cell death and infection: a double-edged sword for host and pathogen survival</atitle><jtitle>The Journal of cell biology</jtitle><addtitle>J Cell Biol</addtitle><date>2011-12-12</date><risdate>2011</risdate><volume>195</volume><issue>6</issue><spage>931</spage><epage>942</epage><pages>931-942</pages><issn>0021-9525</issn><eissn>1540-8140</eissn><coden>JCLBA3</coden><abstract>Host cell death is an intrinsic immune defense mechanism in response to microbial infection. However, bacterial pathogens use many strategies to manipulate the host cell death and survival pathways to enhance their replication and survival. This manipulation is quite intricate, with pathogens often suppressing cell death to allow replication and then promoting it for dissemination. Frequently, these effects are exerted through modulation of the mitochondrial pro-death, NF-κB-dependent pro-survival, and inflammasome-dependent host cell death pathways during infection. Understanding the molecular details by which bacterial pathogens manipulate cell death pathways will provide insight into new therapeutic approaches to control infection.</abstract><cop>United States</cop><pub>Rockefeller University Press</pub><pmid>22123830</pmid><doi>10.1083/jcb.201108081</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-9525 |
| ispartof | The Journal of cell biology, 2011-12, Vol.195 (6), p.931-942 |
| issn | 0021-9525 1540-8140 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3241725 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Apoptosis Apoptosis - immunology Bacterial Infections - immunology Bacterial Infections - pathology Host-Pathogen Interactions - immunology Humans Infections Inflammasomes - immunology Mice Mitochondria Mitochondria - immunology Necrosis Pathogens Phagocytes - immunology Phagocytes - microbiology Reviews Signal transduction |
| title | Cell death and infection: a double-edged sword for host and pathogen survival |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T00%3A44%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cell%20death%20and%20infection:%20a%20double-edged%20sword%20for%20host%20and%20pathogen%20survival&rft.jtitle=The%20Journal%20of%20cell%20biology&rft.au=Ashida,%20Hiroshi&rft.date=2011-12-12&rft.volume=195&rft.issue=6&rft.spage=931&rft.epage=942&rft.pages=931-942&rft.issn=0021-9525&rft.eissn=1540-8140&rft.coden=JCLBA3&rft_id=info:doi/10.1083/jcb.201108081&rft_dat=%3Cproquest_pubme%3E2537660121%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=910973213&rft_id=info:pmid/22123830&rfr_iscdi=true |