Toll-like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts

Increased levels of genes in the type I interferon (IFN) pathway have been observed in patients with systemic sclerosis (SSc), or scleroderma. How type I IFN regulates the dermal fibroblast and its participation in the development of dermal fibrosis is not known. We hypothesized that one mechanism b...

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Veröffentlicht in:	Arthritis research & therapy 2011-01, Vol.13 (1), p.R3-R3, Article R3
Hauptverfasser:	Agarwal, Sandeep K, Wu, Minghua, Livingston, Christopher K, Parks, Donald H, Mayes, Maureen D, Arnett, Frank C, Tan, Filemon K
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Development and progression Fibroblasts Fibroblasts - immunology Fibroblasts - metabolism Fibrosis Genetic aspects Genetic regulation Humans Immunohistochemistry Interferon Interferon-alpha - immunology Interferon-alpha - metabolism Mice Mice, Inbred C57BL Physiological aspects Real-Time Polymerase Chain Reaction Scleroderma (Disease) Scleroderma, Systemic - immunology Scleroderma, Systemic - metabolism Scleroderma, Systemic - pathology Skin - immunology Skin - metabolism Skin - pathology Systemic scleroderma TLR3 Toll-Like Receptor 3 - biosynthesis Toll-Like Receptor 3 - immunology Up-Regulation
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