Cdh1 Regulates Osteoblast Function through an APC/C-Independent Modulation of Smurf1

The APC/Cdh1 E3 ubiquitin ligase plays an essential role in both mitotic exit and G1/S transition by targeting key cell-cycle regulators for destruction. There is mounting evidence indicating that Cdh1 has other functions in addition to cell-cycle regulation. However, it remains unclear whether thes...

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Veröffentlicht in:	Molecular cell 2011-12, Vol.44 (5), p.721-733
Hauptverfasser:	Wan, Lixin, Zou, Weiguo, Gao, Daming, Inuzuka, Hiroyuki, Fukushima, Hidefumi, Berg, Anders H., Drapp, Rebecca, Shaik, Shavali, Hu, Dorothy, Lester, Chantel, Eguren, Manuel, Malumbres, Marcos, Glimcher, Laurie H., Wei, Wenyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaphase-Promoting Complex-Cyclosome Animals Cadherins - metabolism Cdh1 Proteins cell cycle Cell Cycle Proteins - metabolism Cell Differentiation Humans MAP Kinase Kinase Kinase 2 - metabolism MAP Kinase Signaling System Mice osteoblasts Osteoblasts - cytology Osteoblasts - metabolism osteoporosis Protein Binding Protein Multimerization signal transduction ubiquitin-protein ligase Ubiquitin-Protein Ligase Complexes - metabolism Ubiquitin-Protein Ligases - antagonists & inhibitors Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism Ubiquitination
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