Sustained axon regeneration induced by co-deletion of PTEN and SOCS3

Nerve regeneration at a distance Long-range extensive repair following nerve damage has been demonstrated in the peripheral nervous system, but such robust regeneration is rare in the central nervous system. Previous studies have observed some repair following molecular manipulations of the regenera...

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Veröffentlicht in:	Nature (London) 2011-12, Vol.480 (7377), p.372-375
Hauptverfasser:	Sun, Fang, Park, Kevin K., Belin, Stephane, Wang, Dongqing, Lu, Tao, Chen, Gang, Zhang, Kang, Yeung, Cecil, Feng, Guoping, Yankner, Bruce A., He, Zhigang
Format:	Artikel
Sprache:	eng
Schlagworte:	631/136 631/378/1687 631/45/612/1234 631/80/86 Analysis Animals Axonal transport Axons Axons - pathology Axons - physiology Biological and medical sciences Cell Growth Processes - genetics Central nervous system Central nervous system diseases Control Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation Genetic aspects Growth Humanities and Social Sciences Immune response letter Medical research Mice Mice, Inbred C57BL multidisciplinary Nerve Crush Nerve Regeneration - physiology Nervous system Optic nerve Optic Nerve - cytology Optic Nerve - growth & development Optic Nerve - pathology Optic Nerve Injuries - genetics Optic Nerve Injuries - metabolism Optic Nerve Injuries - pathology Physiological aspects PTEN Phosphohydrolase - deficiency PTEN Phosphohydrolase - genetics Regeneration Regrowth Regulation Retinal Ganglion Cells - metabolism Rodents Science Signal Transduction STAT3 Transcription Factor - metabolism Suppressor of Cytokine Signaling 3 Protein Suppressor of Cytokine Signaling Proteins - deficiency Suppressor of Cytokine Signaling Proteins - genetics Transducers Tumor suppressor genes Vertebrates: nervous system and sense organs
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