Image-Guided Tumor-Selective Radioiodine Therapy of Liver Cancer After Systemic Nonviral Delivery of the Sodium Iodide Symporter Gene

We reported the induction of tumor-selective iodide uptake and therapeutic efficacy of (131)I in a hepatocellular carcinoma (HCC) xenograft mouse model, using novel polyplexes based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG), and coupled with the epidermal growth factor...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Human gene therapy 2011-12, Vol.22 (12), p.1563-1574
Hauptverfasser:	KLUTZ, Kathrin, WILLHAUCK, Michael J, GÖKE, Burkhard, WAGNER, Ernst, OGRIS, Manfred, SPITZWEG, Christine, DOHMEN, Christian, WUNDERLICH, Nathalie, KNOOP, Kerstin, ZACH, Christian, SENEKOWITSCH-SCHMIDTKE, Reingard, GILDEHAUS, Franz-Josef, ZIEGLER, Sibylle, FURST, Sebastian
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Applied cell therapy and gene therapy Biological and medical sciences Biotechnology Blotting, Western Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy Cell physiology Cell Proliferation Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Combined Modality Therapy Drug Delivery Systems Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Gene therapy Gene Transfer Techniques Genetic Therapy Genetic Vectors - administration & dosage Health. Pharmaceutical industry Humans Image Processing, Computer-Assisted Immunoenzyme Techniques Industrial applications and implications. Economical aspects Iodine Radioisotopes - pharmacokinetics Iodine Radioisotopes - therapeutic use Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms - therapy Medical sciences Mice Mice, Nude Molecular and cellular biology Multimodal Imaging Polyethylene Glycols - administration & dosage Polyethyleneimine - administration & dosage Positron-Emission Tomography Radiotherapy Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Symporters - genetics Tomography, X-Ray Computed Transfusions. Complications. Transfusion reactions. Cell and gene therapy Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!