Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist

Lysophosphatidic acid (LPA) is a bioactive compound that has gained attention due to its role in neoplastic diseases. Our group has developed a potent dual LPA1/LPA3 receptor antagonist, VPC51098 (LPA1 IC(50) = 84 nM, LPA1 IC(50) = 48 nM) that contained a labile phosphate head group. This lability h...

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Veröffentlicht in:	MedChemComm 2011-03, Vol.2 (4), p.325-330
Hauptverfasser:	East, James E, Carter, Karen M, Kennedy, Perry C, Schulte, Nancy A, Toews, Myron L, Lynch, Kevin R, Macdonald, Timothy L
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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