Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin

Mutation in isocitrate dehydrogenase 1 (IDH1) at R132 (IDH1(R132MUT)) is frequent in low-grade diffuse gliomas and, within glioblastoma (GBM), has been proposed as a marker for GBMs that arise by transformation from lower-grade gliomas, regardless of clinical history. To determine how GBMs arising w...

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Veröffentlicht in:	Journal of clinical oncology 2011-12, Vol.29 (34), p.4482-4490
Hauptverfasser:	LAI, Albert, KHARBANDA, Samir, ELLINGSON, Benjamin M, BOWERS, Chauncey W, SORIANO, Robert H, SCHMIDT, Nils O, MOHAN, Sankar, YONG, William H, SESHAGIRI, Somasekar, MODRUSAN, Zora, ZHAOSHI JIANG, ALDAPE, Kenneth D, POPE, Whitney B, MISCHEL, Paul S, LIAU, Linda M, ESCOVEDO, Cameron J, WEIDONG CHEN, PHIOANH LEIA NGHIEMPHU, DAVID JAMES, C, PRADOS, Michael D, WESTPHAL, Manfred, LAMSZUS, Katrin, CLOUGHESY, Timothy, TRAN, Anh, PHILLIPS, Heidi S, SOLIS, Orestes E, PEALE, Franklin, FORREST, William F, PUJARA, Kanan, CARRILLO, Jose A, PANDITA, Ajay
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Base Sequence Biological and medical sciences Brain Neoplasms - genetics Cell Lineage Cell Transformation, Neoplastic - genetics Evolution, Molecular Female Genes, p53 Glioblastoma - genetics Glioma - genetics Humans Isocitrate Dehydrogenase - genetics Male Medical sciences Middle Aged Mutation Neurology Original Reports Tumors Tumors of the nervous system. Phacomatoses
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