Insulin Binding and Insulin Action in Cultured Fibroblasts: Significant Differences between a Phosphoglucose Isomerase-Deficient Mutant and the Parental Strain

The interrelationships of hexose feeding and insulin action were studied in the Chinese hamster fibroblast cell lines 023 and DS-7. The latter, derived from 023 and deficient in phosphoglucose isomerase, has been used to map the metabolic requirements for aldohexose-mediated down-regulation or ``cur...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1986-06, Vol.83 (11), p.3684-3687
Hauptverfasser:	Wilson, Charles, Peterson, Scott W., Ullrey, Donna B., Kalckar, Herman M.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-O-Methylglucose Animals Biological and medical sciences Biological Transport Cell Line Cell lines Cell physiology Cellular metabolism Cricetinae Cultured cells Fibroblasts Fundamental and applied biological sciences. Psychology Glucose - metabolism Glucose-6-Phosphate Isomerase - genetics Glucose-6-Phosphate Isomerase - metabolism Hexoses Hydrogen-Ion Concentration Insulin Insulin - metabolism Kinetics Membrane and intracellular transports Methylglucosides - metabolism Molecular and cellular biology Monosaccharide Transport Proteins - metabolism Mutation Physiological regulation Receptor, Insulin - metabolism Receptors Sugars
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