Methylation of L1Hs promoters is lower on the inactive X, has a tendency of being higher on autosomes in smaller genomes and shows inter-individual variability at some loci

LINE-1 repeats account for ∼17% of the human genome. Little is known about their individual methylation patterns, because their repetitive, almost identical sequences make them difficult to be individually targeted. Here, we used bisulfite conversion to study methylation at individual LINE-1 repeats...

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Veröffentlicht in:	Human molecular genetics 2012-01, Vol.21 (1), p.219-235
Hauptverfasser:	Singer, Heike, Walier, Maja, Nüsgen, Nicole, Meesters, Christian, Schreiner, Felix, Woelfle, Joachim, Fimmers, Rolf, Wienker, Thomas, Kalscheuer, Vera M., Becker, Tim, Schwaab, Rainer, Oldenburg, Johannes, El-Maarri, Osman
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Chromosomes, Human, X - genetics DNA Methylation Female Genome Size Humans Klinefelter Syndrome - genetics Long Interspersed Nucleotide Elements Male Mutagenesis, Insertional Promoter Regions, Genetic Turner Syndrome - genetics X Chromosome Inactivation Young Adult
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