Curcumin Differentially Regulates Endoplasmic Reticulum Stress through Transcriptional Corepressor SMILE (Small Heterodimer Partner-interacting Leucine Zipper Protein)-mediated Inhibition of CREBH (cAMP Responsive Element-binding Protein H)

Curcumin (diferuloylmethane), a major active component of turmeric (Curcuma longa), is a natural polyphenolic compound. Herein the effect of curcumin on endoplasmic reticulum (ER) stress responsive gene expression was investigated. We report that curcumin induces transcriptional corepressor small he...

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Veröffentlicht in:	The Journal of biological chemistry 2011-12, Vol.286 (49), p.41972-41984
Hauptverfasser:	Misra, Jagannath, Chanda, Dipanjan, Kim, Don-kyu, Li, Tiangang, Koo, Seung-Hoi, Back, Sung-Hoon, Chiang, John Y.L., Choi, Hueng-Sik
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 6 - metabolism Animals Antioxidants Antioxidants - metabolism ATF6 Basic-Leucine Zipper Transcription Factors - metabolism Cell Line, Tumor CREBH Curcumin - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Dimerization Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress Gene Regulation Heat-Shock Proteins - metabolism Humans Mice Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha PGC-1α Protein-Serine-Threonine Kinases - metabolism Rats RNA-Binding Proteins - metabolism SMILE Trans-Activators - metabolism Transcription Coactivators Transcription Factors Transcription Factors - metabolism Transcription Repressor
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