Molecular Determinants of CaV2.1 Channel Regulation by Calcium-binding Protein-1

Presynaptic CaV2.1 channels, which conduct P/Q-type Ca2+ currents, initiate synaptic transmission at most synapses in the central nervous system. Regulation of CaV2.1 channels by CaM contributes significantly to short term facilitation and rapid depression of synaptic transmission. Short term synapt...

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Veröffentlicht in:	The Journal of biological chemistry 2011-12, Vol.286 (49), p.41917-41923
Hauptverfasser:	Few, Alexandra P., Nanou, Evanthia, Scheuer, Todd, Catterall, William A.
Format:	Artikel
Sprache:	eng
Schlagworte:	CaBP1 Calcium Calcium - chemistry Calcium - metabolism Calcium Channels Calcium Channels, N-Type - metabolism Calcium Sensor Proteins Calcium-binding Proteins Calcium-Binding Proteins - metabolism Calmodulin Calmodulin - chemistry Cell Line Electrophysiology - methods Facilitation Gene Expression Regulation Humans Inactivation Models, Biological Neurobiology Neuronal Plasticity Neurons - metabolism Protein Binding Protein Structure, Tertiary Recombinant Fusion Proteins - chemistry Synaptic Plasticity Synaptic Transmission
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