Transthiocarbamoylation of Proteins by Thiolated Isothiocyanates

Isothiocyanates, membrane-permeable electrophiles that form adducts with thiols, have been suggested to have important medical benefits. Here we shed light on isothiocyanate-thiol conjugates and studied their electrophilic potential transferring an isothiocyanate moiety to cellular proteins. When we...

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Veröffentlicht in:	The Journal of biological chemistry 2011-12, Vol.286 (49), p.42150-42161
Hauptverfasser:	Shibata, Takahiro, Kimura, Yuuki, Mukai, Akihiro, Mori, Hitoshi, Ito, Sohei, Asaka, Yukio, Oe, Sho, Tanaka, Hiroshi, Takahashi, Takashi, Uchida, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caco-2 Cells Chemical Biology Escherichia coli - metabolism Heat Shock Protein Hsp90 HSP90 Heat-Shock Proteins - chemistry Humans Image Processing, Computer-Assisted Immunohistochemistry - methods Immunoprecipitation - methods Isothiocyanate Isothiocyanates - chemistry Post-translational Modification Protein Processing, Post-Translational Proteins - chemistry RNA, Small Interfering - metabolism Signal Transduction Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods Sulfhydryl Sulfhydryl Compounds - chemistry Wolves
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