Gastric Inhibitory Peptide Controls Adipose Insulin Sensitivity via Activation of cAMP-response Element-binding Protein and p110β Isoform of Phosphatidylinositol 3-Kinase

Gastric inhibitory peptide (GIP) is an incretin hormone secreted in response to food intake. The best known function of GIP is to enhance glucose-dependent insulin secretion from pancreatic β-cells. Extra-pancreatic effects of GIP primarily occur in adipose tissues. Here, we demonstrate that GIP inc...

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Veröffentlicht in:	The Journal of biological chemistry 2011-12, Vol.286 (50), p.43062-43070
Hauptverfasser:	Mohammad, Sameer, Ramos, Lavoisier S., Buck, Jochen, Levin, Lonny R., Rubino, Francesco, McGraw, Timothy E.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 Cells Adipocytes - drug effects Adipocytes - metabolism Adipose Tissue - metabolism Animals Class Ia Phosphatidylinositol 3-Kinase - metabolism Cyclic AMP - metabolism Cyclic AMP Response Element-Binding Protein - metabolism Electrophoresis, Polyacrylamide Gel G Protein-coupled Receptors (GPCR) Gastric Inhibitory Polypeptide - pharmacology Glut4 Immunoblotting Immunoprecipitation Insulin Insulin Resistance Insulin Sensitivity Metabolism Mice Phosphatidylinositol 3-Kinase Receptor, Insulin - metabolism
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