AKAP220 Protein Organizes Signaling Elements That Impact Cell Migration

Cell movement requires the coordinated reception, integration, and processing of intracellular signals. We have discovered that the protein kinase A anchoring protein AKAP220 interacts with the cytoskeletal scaffolding protein IQGAP1 to influence cell motility. AKAP220/IQGAP1 networks receive and in...

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Veröffentlicht in:	The Journal of biological chemistry 2011-11, Vol.286 (45), p.39269-39281
Hauptverfasser:	Logue, Jeremy S., Whiting, Jennifer L., Tunquist, Brian, Sacks, David B., Langeberg, Lorene K., Wordeman, Linda, Scott, John D.
Format:	Artikel
Sprache:	eng
Schlagworte:	A Kinase Anchor Proteins - genetics A Kinase Anchor Proteins - metabolism Akap Calcium - metabolism Calmodulin - genetics Calmodulin - metabolism Cell Line, Tumor Cell Movement - physiology Cellular Regulation Cyclic AMP - genetics Cyclic AMP - metabolism Gene Silencing Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Glycogen Synthase Kinase 3 beta Humans Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubules - genetics Microtubules - metabolism Protein Kinases Protein-Protein Interactions ras GTPase-Activating Proteins - genetics ras GTPase-Activating Proteins - metabolism Second Messenger Systems - physiology Signal Transduction
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