Evaluation of Bone Toxicity in Various Bones of Aged Rats

The aim of the present study was to provide a method for evaluating bone toxicity induced by drugs in various bones in aged rats. Male Crl:CD (SD) rats at 46 weeks of age were administered 15 mg/m2 body surface area of doxorubicin, which effects the growth plate in weanling rats, weekly for 9 weeks...

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Veröffentlicht in:	Journal of Toxicologic Pathology 2011, Vol.24(1), pp.41-48
Hauptverfasser:	Noguchi, Chihiro, Miyata, Hiroto, Sato, Yasushi, Iwaki, Yoshinobu, Okuyama, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	bone toxicity doxorubicin epiphyseal closure growth plate Original rat
Online-Zugang:	Volltext
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