Monocyte/macrophage chemokine receptor CCR2 mediates diabetic renal injury

Monocyte/macrophage recruitment correlates strongly with the progression of renal impairment in diabetic nephropathy (DN). C-C chemokine receptor (CCR)2 regulates monocyte/macrophage migration into injured tissues. However, the direct role of CCR2-mediated monocyte/macrophage recruitment in diabetic...

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Veröffentlicht in:	American journal of physiology. Renal physiology 2011-12, Vol.301 (6), p.F1358-F1366
Hauptverfasser:	Awad, Alaa S, Kinsey, Gilbert R, Khutsishvili, Konstantine, Gao, Ting, Bolton, W Kline, Okusa, Mark D
Format:	Artikel
Sprache:	eng
Schlagworte:	Albuminuria - drug therapy Albuminuria - pathology Animals Blood Glucose - drug effects Blood Glucose - metabolism Blood Urea Nitrogen Cell Movement - drug effects Chemokines Creatinine - blood Diabetes Mellitus, Experimental - drug therapy Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetic Nephropathies - drug therapy Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology Glucose Kidney diseases Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred C57BL Monocytes - drug effects Monocytes - metabolism Receptors, CCR2 - antagonists & inhibitors Receptors, CCR2 - genetics Receptors, CCR2 - metabolism Rodents Tissues
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