Script-driven imagery of self-injurious behavior in patients with borderline personality disorder: a pilot FMRI study
Objective: Self‐injurious behavior (SIB) is one of the most distinctive features of borderline personality disorder (BPD) and related to impulsivity and emotional dysregulation. Method: Female patients with BPD (n = 11) and healthy controls (n = 10) underwent functional magnetic resonance imaging...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2010-01, Vol.121 (1), p.41-51 |
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| container_title | Acta psychiatrica Scandinavica |
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| creator | Kraus, A. Valerius, G. Seifritz, E. Ruf, M. Bremner, J. D. Bohus, M. Schmahl, C. |
| description | Objective: Self‐injurious behavior (SIB) is one of the most distinctive features of borderline personality disorder (BPD) and related to impulsivity and emotional dysregulation.
Method: Female patients with BPD (n = 11) and healthy controls (n = 10) underwent functional magnetic resonance imaging while listening to a standardized script describing an act of self‐injury. Experimental sections of the script were contrasted to the neutral baseline section and group‐specific brain activities were compared.
Results: While imagining the reactions to a situation triggering SIB, patients with BPD showed significantly less activation in the orbitofrontal cortex compared with controls. Furthermore, only patients with BPD showed increased activity in the dorsolateral prefrontal cortex during this section and a decrease in the mid‐cingulate while imagining the self‐injurious act itself.
Conclusion: This pattern of activation preliminary suggests an association with diminished emotion regulation, impulse control as well as with response selection and reappraisal during the imagination of SIB. |
| doi_str_mv | 10.1111/j.1600-0447.2009.01417.x |
| format | Article |
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Method: Female patients with BPD (n = 11) and healthy controls (n = 10) underwent functional magnetic resonance imaging while listening to a standardized script describing an act of self‐injury. Experimental sections of the script were contrasted to the neutral baseline section and group‐specific brain activities were compared.
Results: While imagining the reactions to a situation triggering SIB, patients with BPD showed significantly less activation in the orbitofrontal cortex compared with controls. Furthermore, only patients with BPD showed increased activity in the dorsolateral prefrontal cortex during this section and a decrease in the mid‐cingulate while imagining the self‐injurious act itself.
Conclusion: This pattern of activation preliminary suggests an association with diminished emotion regulation, impulse control as well as with response selection and reappraisal during the imagination of SIB.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/j.1600-0447.2009.01417.x</identifier><identifier>PMID: 19522883</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; borderline personality disorder ; Borderline Personality Disorder - diagnosis ; Borderline Personality Disorder - epidemiology ; Borderline Personality Disorder - physiopathology ; Brain - physiopathology ; Brain Mapping ; Comorbidity ; Emotions - physiology ; Female ; Functional Laterality - physiology ; Humans ; Image Processing, Computer-Assisted ; Imagination - physiology ; impulsive behavior ; Impulsive Behavior - diagnosis ; Impulsive Behavior - physiopathology ; Life Change Events ; Magnetic Resonance Imaging - statistics & numerical data ; Medical sciences ; Mental Disorders - diagnosis ; Mental Disorders - epidemiology ; Mental Disorders - physiopathology ; Neuroses ; Oxygen - blood ; pain ; Pain Threshold - physiology ; Patients ; Personality disorders ; Pilot Projects ; Prefrontal Cortex - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Reaction Time - physiology ; Self destructive behavior ; self-injurious behavior ; Self-Injurious Behavior - diagnosis ; Self-Injurious Behavior - epidemiology ; Self-Injurious Behavior - physiopathology</subject><ispartof>Acta psychiatrica Scandinavica, 2010-01, Vol.121 (1), p.41-51</ispartof><rights>2009 John Wiley & Sons A/S</rights><rights>2015 INIST-CNRS</rights><rights>2010 John Wiley & Sons A/S</rights><rights>2009 John Wiley & Sons A/S 2009</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6007-48df27dc6b63d10c7e79853610384deee666bcf49651f52ee9438f0a8ca72c673</citedby><cites>FETCH-LOGICAL-c6007-48df27dc6b63d10c7e79853610384deee666bcf49651f52ee9438f0a8ca72c673</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0447.2009.01417.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0447.2009.01417.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,777,781,882,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22228661$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19522883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kraus, A.</creatorcontrib><creatorcontrib>Valerius, G.</creatorcontrib><creatorcontrib>Seifritz, E.</creatorcontrib><creatorcontrib>Ruf, M.</creatorcontrib><creatorcontrib>Bremner, J. D.</creatorcontrib><creatorcontrib>Bohus, M.</creatorcontrib><creatorcontrib>Schmahl, C.</creatorcontrib><title>Script-driven imagery of self-injurious behavior in patients with borderline personality disorder: a pilot FMRI study</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective: Self‐injurious behavior (SIB) is one of the most distinctive features of borderline personality disorder (BPD) and related to impulsivity and emotional dysregulation.
Method: Female patients with BPD (n = 11) and healthy controls (n = 10) underwent functional magnetic resonance imaging while listening to a standardized script describing an act of self‐injury. Experimental sections of the script were contrasted to the neutral baseline section and group‐specific brain activities were compared.
Results: While imagining the reactions to a situation triggering SIB, patients with BPD showed significantly less activation in the orbitofrontal cortex compared with controls. Furthermore, only patients with BPD showed increased activity in the dorsolateral prefrontal cortex during this section and a decrease in the mid‐cingulate while imagining the self‐injurious act itself.
Conclusion: This pattern of activation preliminary suggests an association with diminished emotion regulation, impulse control as well as with response selection and reappraisal during the imagination of SIB.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>borderline personality disorder</subject><subject>Borderline Personality Disorder - diagnosis</subject><subject>Borderline Personality Disorder - epidemiology</subject><subject>Borderline Personality Disorder - physiopathology</subject><subject>Brain - physiopathology</subject><subject>Brain Mapping</subject><subject>Comorbidity</subject><subject>Emotions - physiology</subject><subject>Female</subject><subject>Functional Laterality - physiology</subject><subject>Humans</subject><subject>Image Processing, Computer-Assisted</subject><subject>Imagination - physiology</subject><subject>impulsive behavior</subject><subject>Impulsive Behavior - diagnosis</subject><subject>Impulsive Behavior - physiopathology</subject><subject>Life Change Events</subject><subject>Magnetic Resonance Imaging - statistics & numerical data</subject><subject>Medical sciences</subject><subject>Mental Disorders - diagnosis</subject><subject>Mental Disorders - epidemiology</subject><subject>Mental Disorders - physiopathology</subject><subject>Neuroses</subject><subject>Oxygen - blood</subject><subject>pain</subject><subject>Pain Threshold - physiology</subject><subject>Patients</subject><subject>Personality disorders</subject><subject>Pilot Projects</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Reaction Time - physiology</subject><subject>Self destructive behavior</subject><subject>self-injurious behavior</subject><subject>Self-Injurious Behavior - diagnosis</subject><subject>Self-Injurious Behavior - epidemiology</subject><subject>Self-Injurious Behavior - physiopathology</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1vEzEQhlcIREPhLyALCTht8NfaXg5IJaKlUvhQC4Wb5XhnG4fNerF30-Tf4zRRChwQvtjWPPNqZt7JMkTwmKTzajEmAuMccy7HFONyjAkncry-l40OgfvZCGNMclHi70fZoxgX6VsQrB5mR6QsKFWKjbLh0gbX9XkV3Apa5JbmGsIG-RpFaOrctYshOD9ENIO5WTkfkGtRZ3oHbR_RjevnaOZDBaFxLaAOQvStaVy_QZWLt4HXyKDONb5Hpx8uzlHsh2rzOHtQmybCk_19nH09ffdl8j6ffjo7n5xMc5u6kDlXVU1lZcVMsIpgK0GWqmCCYKZ4BQBCiJmteSkKUhcUoORM1dgoayS1QrLj7M1OtxtmS6hsKjqYRnch9Rk22hun_4y0bq6v_UozypgUZRJ4uRcI_ucAsddLFy00jWkhTUVLxoQqCVeJfPFPkhIqORU8gc_-Ahd-CGloUSdbVIETlSC1g2zwMQaoDzUTrLcroBd667TeOq23K6BvV0CvU-rT33u-S9x7noDne8BEa5o6mNa6eOBoOkoIcje8G9fA5r8L0CeTz5fbZxLIdwIu9rA-CJjwQydvZKG_fTzTF8VUXl3xt2mUvwD3Od24</recordid><startdate>201001</startdate><enddate>201001</enddate><creator>Kraus, A.</creator><creator>Valerius, G.</creator><creator>Seifritz, E.</creator><creator>Ruf, M.</creator><creator>Bremner, J. D.</creator><creator>Bohus, M.</creator><creator>Schmahl, C.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201001</creationdate><title>Script-driven imagery of self-injurious behavior in patients with borderline personality disorder: a pilot FMRI study</title><author>Kraus, A. ; Valerius, G. ; Seifritz, E. ; Ruf, M. ; Bremner, J. D. ; Bohus, M. ; Schmahl, C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6007-48df27dc6b63d10c7e79853610384deee666bcf49651f52ee9438f0a8ca72c673</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>borderline personality disorder</topic><topic>Borderline Personality Disorder - diagnosis</topic><topic>Borderline Personality Disorder - epidemiology</topic><topic>Borderline Personality Disorder - physiopathology</topic><topic>Brain - physiopathology</topic><topic>Brain Mapping</topic><topic>Comorbidity</topic><topic>Emotions - physiology</topic><topic>Female</topic><topic>Functional Laterality - physiology</topic><topic>Humans</topic><topic>Image Processing, Computer-Assisted</topic><topic>Imagination - physiology</topic><topic>impulsive behavior</topic><topic>Impulsive Behavior - diagnosis</topic><topic>Impulsive Behavior - physiopathology</topic><topic>Life Change Events</topic><topic>Magnetic Resonance Imaging - statistics & numerical data</topic><topic>Medical sciences</topic><topic>Mental Disorders - diagnosis</topic><topic>Mental Disorders - epidemiology</topic><topic>Mental Disorders - physiopathology</topic><topic>Neuroses</topic><topic>Oxygen - blood</topic><topic>pain</topic><topic>Pain Threshold - physiology</topic><topic>Patients</topic><topic>Personality disorders</topic><topic>Pilot Projects</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Reaction Time - physiology</topic><topic>Self destructive behavior</topic><topic>self-injurious behavior</topic><topic>Self-Injurious Behavior - diagnosis</topic><topic>Self-Injurious Behavior - epidemiology</topic><topic>Self-Injurious Behavior - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kraus, A.</creatorcontrib><creatorcontrib>Valerius, G.</creatorcontrib><creatorcontrib>Seifritz, E.</creatorcontrib><creatorcontrib>Ruf, M.</creatorcontrib><creatorcontrib>Bremner, J. D.</creatorcontrib><creatorcontrib>Bohus, M.</creatorcontrib><creatorcontrib>Schmahl, C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kraus, A.</au><au>Valerius, G.</au><au>Seifritz, E.</au><au>Ruf, M.</au><au>Bremner, J. D.</au><au>Bohus, M.</au><au>Schmahl, C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Script-driven imagery of self-injurious behavior in patients with borderline personality disorder: a pilot FMRI study</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2010-01</date><risdate>2010</risdate><volume>121</volume><issue>1</issue><spage>41</spage><epage>51</epage><pages>41-51</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><coden>APYSA9</coden><abstract>Objective: Self‐injurious behavior (SIB) is one of the most distinctive features of borderline personality disorder (BPD) and related to impulsivity and emotional dysregulation.
Method: Female patients with BPD (n = 11) and healthy controls (n = 10) underwent functional magnetic resonance imaging while listening to a standardized script describing an act of self‐injury. Experimental sections of the script were contrasted to the neutral baseline section and group‐specific brain activities were compared.
Results: While imagining the reactions to a situation triggering SIB, patients with BPD showed significantly less activation in the orbitofrontal cortex compared with controls. Furthermore, only patients with BPD showed increased activity in the dorsolateral prefrontal cortex during this section and a decrease in the mid‐cingulate while imagining the self‐injurious act itself.
Conclusion: This pattern of activation preliminary suggests an association with diminished emotion regulation, impulse control as well as with response selection and reappraisal during the imagination of SIB.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19522883</pmid><doi>10.1111/j.1600-0447.2009.01417.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Adult and adolescent clinical studies Biological and medical sciences borderline personality disorder Borderline Personality Disorder - diagnosis Borderline Personality Disorder - epidemiology Borderline Personality Disorder - physiopathology Brain - physiopathology Brain Mapping Comorbidity Emotions - physiology Female Functional Laterality - physiology Humans Image Processing, Computer-Assisted Imagination - physiology impulsive behavior Impulsive Behavior - diagnosis Impulsive Behavior - physiopathology Life Change Events Magnetic Resonance Imaging - statistics & numerical data Medical sciences Mental Disorders - diagnosis Mental Disorders - epidemiology Mental Disorders - physiopathology Neuroses Oxygen - blood pain Pain Threshold - physiology Patients Personality disorders Pilot Projects Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Reaction Time - physiology Self destructive behavior self-injurious behavior Self-Injurious Behavior - diagnosis Self-Injurious Behavior - epidemiology Self-Injurious Behavior - physiopathology |
| title | Script-driven imagery of self-injurious behavior in patients with borderline personality disorder: a pilot FMRI study |
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