Insertional mutagenesis identifies multiple networks of co-operating genes driving intestinal tumorigenesis

The evolution of colorectal cancer suggests the involvement of many genes. We performed insertional mutagenesis with the Sleeping Beauty (SB) transposon system in mice carrying germline or somatic Apc mutation. Analysis of common insertion sites (CISs) isolated from 446 tumors revealed many hundreds...

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Veröffentlicht in:	Nature genetics 2011-11, Vol.43 (12), p.1202-1209
Hauptverfasser:	March, H. Nikki, Rust, Alistair G., Wright, Nicholas A., Hoeve, Jelle ten, de Ridder, Jeroen, Eldridge, Matthew, van der Weyden, Louise, Berns, Anton, Gadiot, Jules, Uren, Anthony, Kemp, Richard, Arends, Mark J., Wessels, Lodewyk F. A., Winton, Douglas J., Adams, David J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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