Azidohomoalanine: A Conformationally Sensitive IR Probe of Protein Folding, Protein Structure, and Electrostatics

Highly sensitive: The azido analogue of methionine, azidohomoalanine (see picture), is shown to be a sensitive IR probe of protein structure, folding, and electrostatics, as demonstrated for ribosomal protein NTL9. It can be readily incorporated in to proteins, and the azido frequency is significant...

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Veröffentlicht in:	Angewandte Chemie (International ed.) 2010-10, Vol.49 (41), p.7473-7475
Hauptverfasser:	Taskent-Sezgin, Humeyra, Chung, Juah, Banerjee, Partha S, Nagarajan, Sureshbabu, Dyer, R. Brian, Carrico, Isaac, Raleigh, Daniel P
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - analogs & derivatives Alanine - chemistry azidohomoalanine electrostatics infrared spectroscopy Models, Molecular Protein Conformation Protein Folding protein modifications Protein Structure, Tertiary Proteins - chemistry Ribosomal Proteins - chemistry Spectrophotometry, Infrared - methods Static Electricity
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