Identification of Key Residues Involved in the Dimerization of the Secretory Na+–K+–2Cl– Cotransporter NKCC1

The “secretory” Na+–K+–2Cl– cotransporter, NKCC1, belongs to the SLC12 gene family of electroneutral cation–chloride cotransporters. A number of these proteins, including NKCC1 itself, exist as homodimers in the membrane, suggesting that this may be a common feature of the SLC12 family. We have prev...

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