RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease

Microglia are critical for amyloid-β peptide (Aβ)-mediated neuronal perturbation relevant to Alzheimer's disease (AD) pathogenesis. We demonstrate that overexpression of receptor for advanced glycation end products (RAGE) in imbroglio exaggerates neuroinflammation, as evidenced by increased pro...

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Veröffentlicht in:	The FASEB journal 2010-04, Vol.24 (4), p.1043-1055
Hauptverfasser:	Fang, Fang, Lue, Lih-Fen, Yan, Shiqiang, Xu, Hongwei, Luddy, John S, Chen, Doris, Walker, Douglas G, Stern, David M, Yan, Shifang, Schmidt, Ann Marie, Chen, John X, Yan, Shirley ShiDu
Format:	Artikel
Sprache:	eng
Schlagworte:	animal model Aβ-binding protein cytokine microglia/neuron interaction Research Communications
Online-Zugang:	Volltext
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