Humoral immune responses in humanized BLT mice immunized with West Nile virus and HIV‐1 envelope proteins are largely mediated via human CD5+ B cells

Summary BLT mice, constructed by surgical implantation of human fetal thymus–liver tissues and intravenous delivery of autologous CD34+ haematopoietic stem cells into adult non‐obese diabetic/severe combined immunodeficiency mice, were evaluated for vaccine‐induced humoral immune responses. Followin...

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Veröffentlicht in:	Immunology 2011-12, Vol.134 (4), p.419-433
Hauptverfasser:	Biswas, Subhabrata, Chang, Hong, Sarkis, Phuong T. N., Fikrig, Erol, Zhu, Quan, Marasco, Wayne A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens Antigens, Viral - immunology B-Lymphocytes - immunology BLT CD5 Antigens - immunology Cell Differentiation - immunology Chimera Cytokines Fetal Tissue Transplantation Gene Products, env - immunology HIV-1 - immunology HIVgp140 Human immunodeficiency virus 1 humanized mice Humans IC31 Immune system Immunity, Humoral Immunization Liver - embryology Liver - immunology Liver Transplantation Lymphocytes Medical research Mice Mice, SCID Original Proteins Recombinant Proteins - immunology Species Specificity Thymus Gland - embryology Thymus Gland - immunology Thymus Gland - transplantation Vaccines Vaccines - immunology West Nile virus West Nile virus - immunology West Nile virus envelope
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