Initiation of epileptiform activity in a rat model of periventricular nodular heterotopia

Summary Purpose: Periventricular nodular heterotopia (PNH) is, in humans, often associated with difficult‐to‐control epilepsy. However, there is considerable controversy about the role of the PNH in seizure generation and spread. To study this issue, we have used a rat model in which injection of m...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2011-12, Vol.52 (12), p.2304-2314
Hauptverfasser:	Tschuluun, Naranzogt, Jürgen Wenzel, H., Doisy, Emily T., Schwartzkroin, Philip A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Anticonvulsants. Antiepileptics. Antiparkinson agents Bicuculline Biological and medical sciences Brain Brain slice preparation Cortex Cortical dysplasia Disease Models, Animal Drugs Electrodes Electrographic seizure episode Electrophysiological recording Epilepsy Epilepsy - etiology Epileptic focus Female Firing pattern Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Hippocampus Hippocampus - pathology Hippocampus - physiopathology In Vitro Techniques Interictal spikes Lysine - analogs & derivatives Lysine - drug effects Male Medical sciences Methylazoxymethanol Acetate - analogs & derivatives Methylazoxymethanol Acetate - toxicity Neocortex Neocortex - pathology Neocortex - physiopathology Nervous system (semeiology, syndromes) Neurodevelopmental disorders Neurology Neurons Neurons - drug effects Neurons - metabolism Neurons - physiology Neuropharmacology Periventricular Nodular Heterotopia - chemically induced Periventricular Nodular Heterotopia - complications Periventricular Nodular Heterotopia - pathology Pharmacology. Drug treatments Pregnancy Prenatal Exposure Delayed Effects - chemically induced Prenatal Exposure Delayed Effects - physiopathology Progeny Rats Rats, Sprague-Dawley Rodents Seizures Teratogens - toxicity Ventricle (lateral)
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