Cyclin E and histone H3 levels are regulated by 5-fluorouracil in a DNA mismatch repair-dependent manner

Several studies indicate that the DNA mismatch repair (MMR) system may trigger cytotoxicity upon 5-fluorouracil (5-FU) recognition, but signaling pathways regulated by MMR in response to 5-FU are unknown. We hypothesize that recognition of 5-FU in DNA by MMR proteins trigger specific signaling casca...

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Veröffentlicht in:	Cancer biology & therapy 2010-12, Vol.10 (11), p.1147-1156
Hauptverfasser:	Chung, Heekyung, Chaudhry, Joy, Lopez, Claudia G., Carethers, John M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Antimetabolites, Antineoplastic - pharmacology Binding Biology Bioscience Calcium Cancer Cell Cell Cycle - drug effects Cell Cycle - genetics Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Cycle Cyclin E - biosynthesis Cyclin E - genetics Cyclin E - metabolism DNA Damage DNA Mismatch Repair Fluorouracil - pharmacology Gene Expression - drug effects HCT116 Cells Histones - biosynthesis Histones - genetics Histones - metabolism HT29 Cells Humans Landes MutL Protein Homolog 1 Nuclear Proteins - metabolism Oligonucleotide Array Sequence Analysis Organogenesis Proteins Research Paper Signal Transduction - drug effects
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