Characterization of spontaneously generated prion-like conformers in cultured cells

A distinct conformational transition from the α-helix-rich cellular prion protein (PrPC) into its β-sheet-rich pathological isoform (PrPSc) is the hallmark of prion diseases, a group of fatal transmissible encephalopathies that includes spontaneous and acquired forms. Recently, a PrPSc-like intermed...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2011-10, Vol.3 (10), p.968-984
Hauptverfasser:	Zou, Roger S, Fujioka, Hisashi, Guo, Jian-Ping, Xiao, Xiangzhu, Shimoji, Miyuki, Kong, Crystal, Chen, Cecilia, Tasnadi, Megan, Voma, Chesinta, Yuan, Jue, Moudjou, Mohammed, Laude, Hubert, Petersen, Robert B, Zou, Wen-Quan
Format:	Artikel
Sprache:	eng
Schlagworte:	Algorithms Animals Cells, Cultured Electrophoresis, Gel, Two-Dimensional Endopeptidase K - metabolism Glycosylation Humans Life Sciences Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase - metabolism Molecular Weight Mutation Neurons - cytology Neurons - metabolism Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase - metabolism Prions - chemistry Prions - genetics Prions - metabolism Protein Structure, Secondary Research Paper
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