Animal models to guide clinical drug development in ADHD: lost in translation?

We review strategies for developing animal models for examining and selecting compounds with potential therapeutic benefit in attention‐deficit hyperactivity disorder (ADHD). ADHD is a behavioural disorder of unknown aetiology and pathophysiology. Current understanding suggests that genetic factors...

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Veröffentlicht in:	British journal of pharmacology 2011-10, Vol.164 (4), p.1107-1128
Hauptverfasser:	Wickens, Jeffery R, Hyland, Brian I, Tripp, Gail
Format:	Artikel
Sprache:	eng
Schlagworte:	ADHD amphetamine animal model Animals Attention Deficit Disorder with Hyperactivity - drug therapy Attention Deficit Disorder with Hyperactivity - etiology Attention Deficit Disorder with Hyperactivity - genetics Attention Deficit Disorder with Hyperactivity - physiopathology Attention Deficit Hyperactivity Disorder Disease Models, Animal dopamine Drug Discovery - methods Drug Evaluation, Preclinical Humans hyperactivity Impulsivity inattention methylphenidate noradrenalin Rats Rats, Inbred SHR Rats, Inbred WKY Reproducibility of Results Reviews Translational Medical Research Validity
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