Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies

Vascular endothelial growth factor (VEGF) is a potent regulator of angiogenesis, and its role in cancer biology has been widely studied. Many cancer therapies target angiogenesis, with a focus being on VEGF-mediated signaling such as antibodies to VEGF. However, it is difficult to predict the effect...

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Veröffentlicht in:	BMC systems biology 2011-11, Vol.5 (178), p.193-193
Hauptverfasser:	Finley, Stacey D, Engel-Stefanini, Marianne O, Imoukhuede, P I, Popel, Aleksander S
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Antibodies Antibodies, Neutralizing - pharmacology Antibodies, Neutralizing - therapeutic use Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Blood platelets Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Cancer Care and treatment Cell Line Cells, Cultured Computer Simulation Female Health aspects Humans Influence Kinetics Mice Models, Biological Neovascularization Neuropilin-2 - metabolism Ordinary differential equations Permeability Pharmacokinetics Physiological aspects Proteins Receptors, Vascular Endothelial Growth Factor - metabolism Receptors, Vascular Endothelial Growth Factor - physiology Systems Biology Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - antagonists & inhibitors Vascular Endothelial Growth Factor A - immunology Vascular Endothelial Growth Factor A - metabolism
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