Superficial siderosis associated with abundant τ and α-synuclein accumulation

A Japanese male developed deafness, pyramidal signs and ataxia at age 50. A cerebrospinal fluid examination showed elevated levels of iron, transferrin and ferritin. Brain MRI showed atrophy of the cerebellum and pons as well as potential iron deposits on the surface of the brain. At autopsy, the br...

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Veröffentlicht in:	BMJ case reports 2011-12, Vol.2011
Hauptverfasser:	Takao, Masaki, Murayama, Shigeo, Yoshida, Youji, Mihara, Ban
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged alpha-Synuclein - metabolism Atrophy - diagnosis Autopsy Central Nervous System - metabolism Cerebrum - pathology Fatal Outcome Ferritins - cerebrospinal fluid Findings That Shed New Light on the Possible Pathogenesis of a Disease or an Adverse Effect Hemosiderin - metabolism Hemosiderosis - cerebrospinal fluid Hemosiderosis - complications Hemosiderosis - metabolism Humans Iron - cerebrospinal fluid Japan Magnetic Resonance Imaging Male Middle Aged Other Asian Synucleins - metabolism Transferrin - cerebrospinal fluid
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