mTOR Drives Its Own Activation via SCF βTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

The activities of both mTORC1 and mTORC2 are negatively regulated by their endogenous inhibitor, DEPTOR. As such, the abundance of DEPTOR is a critical determinant in the activity status of the mTOR network. DEPTOR stability is governed by the 26S-proteasome through a largely unknown mechanism. Here...

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Veröffentlicht in:	Molecular cell 2011-10, Vol.44 (2), p.290-303
Hauptverfasser:	Gao, Daming, Inuzuka, Hiroyuki, Tan, Meng-Kwang Marcus, Fukushima, Hidefumi, Locasale, Jason W., Liu, Pengda, Wan, Lixin, Zhai, Bo, Chin, Y. Rebecca, Shaik, Shavali, Lyssiotis, Costas A., Gygi, Steven P., Toker, Alex, Cantley, Lewis C., Asara, John M., Harper, J. Wade, Wei, Wenyi
Format:	Artikel
Sprache:	eng
Schlagworte:	autophagy cell growth kinases mutation non-specific serine/threonine protein kinase phosphorylation
Online-Zugang:	Volltext
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