Fatty Liver, Abdominal Visceral Fat, and Cardiometabolic Risk Factors: The Jackson Heart Study
OBJECTIVE—The goal of this study was to examine whether fatty liver and abdominal visceral adipose tissue (VAT) are jointly associated with cardiometabolic abnormalities. METHODS AND RESULTS—Black participants were from the Jackson Heart Study (n=2882, 65% women) who underwent computed tomography. F...
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| Veröffentlicht in: | Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2011-11, Vol.31 (11), p.2715-2722 |
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| creator | Liu, Jiankang Fox, Caroline S Hickson, DeMarc Bidulescu, Aurelian Carr, J Jeffery Taylor, Herman A |
| description | OBJECTIVE—The goal of this study was to examine whether fatty liver and abdominal visceral adipose tissue (VAT) are jointly associated with cardiometabolic abnormalities.
METHODS AND RESULTS—Black participants were from the Jackson Heart Study (n=2882, 65% women) who underwent computed tomography. Fatty liver was measured by liver attenuation in Hounsfield units (LA), and VAT was quantified volumetrically. Cross-sectional associations between LA, VAT, and cardiometabolic risk factors were assessed using linear and logistic regression, and their joint associations were further examined in 4 subgroupshigh-LA/low-VAT (n=1704), low-LA/low-VAT (n=422), high-LA/high-VAT (n=436), and low-LA/high-VAT (n=320). Both LA and VAT were associated with most cardiometabolic traits (all P |
| doi_str_mv | 10.1161/ATVBAHA.111.234062 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3228266</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>900629110</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4342-9dff0907acea6e8d8305e856c9756733ecfd8b736f7322c1f8d5a52e964328ea3</originalsourceid><addsrcrecordid>eNp9kU9v1DAQxSMEoqXwBTggXxCXpvhP7NgcKoVVy7ZaCaldesTyOhPWbBIX22m1376udilw4eQZvd88j-YVxVuCTwgR5GOzvPnczJvckBPKKizos-KQcFqVlWDiea5xrUouKnpQvIrxJ8a4ohS_LA4okZJLTg-L7-cmpS1auDsIx6hZtX5wo-nRjYsWQi6yfozM2KKZCa3zAySz8r2z6MrFTVZt8iF-Qss1oEtjN9GPaA4mJHSdpnb7unjRmT7Cm_17VHw7P1vO5uXi65eLWbMobcUqWqq267DCtbFgBMhWMsxBcmFVzUXNGNiulauaia5mlFrSyZYbTkGJilEJhh0Vpzvf22k1QGthTHl5fRvcYMJWe-P0v8ro1vqHv9PZTlIhssGHvUHwvyaISQ-PF-h7M4KfolY4n1cRgjNJd6QNPsYA3dMvBOvHXPQ-l9wQvcslD737e7-nkd9BZOD9HjDRmr4LZrQu_uE4lVwplTmx4-59nyDETT_dQ9BrMH1a_2-DB1FLp6o</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>900629110</pqid></control><display><type>article</type><title>Fatty Liver, Abdominal Visceral Fat, and Cardiometabolic Risk Factors: The Jackson Heart Study</title><source>Journals@Ovid Ovid Autoload</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Liu, Jiankang ; Fox, Caroline S ; Hickson, DeMarc ; Bidulescu, Aurelian ; Carr, J Jeffery ; Taylor, Herman A</creator><creatorcontrib>Liu, Jiankang ; Fox, Caroline S ; Hickson, DeMarc ; Bidulescu, Aurelian ; Carr, J Jeffery ; Taylor, Herman A</creatorcontrib><description>OBJECTIVE—The goal of this study was to examine whether fatty liver and abdominal visceral adipose tissue (VAT) are jointly associated with cardiometabolic abnormalities.
METHODS AND RESULTS—Black participants were from the Jackson Heart Study (n=2882, 65% women) who underwent computed tomography. Fatty liver was measured by liver attenuation in Hounsfield units (LA), and VAT was quantified volumetrically. Cross-sectional associations between LA, VAT, and cardiometabolic risk factors were assessed using linear and logistic regression, and their joint associations were further examined in 4 subgroupshigh-LA/low-VAT (n=1704), low-LA/low-VAT (n=422), high-LA/high-VAT (n=436), and low-LA/high-VAT (n=320). Both LA and VAT were associated with most cardiometabolic traits (all P<0.0001), which persisted after additional adjustment for each other (LA, P<0.01–0.0001; VAT, P<0.0001). In bootstrap analyses, the regression coefficient of VAT was significantly greater than LA for triglycerides, high-density lipoprotein cholesterol, impaired glucose, and metabolic syndrome (P=0.009–0.0001). The interaction between LA and VAT was significant for high-density lipoprotein cholesterol (P=0.002), impaired glucose (P=0.003), and metabolic syndrome (P=0.04). Among 4 subgroups, participants with higher VAT and lower LA had higher prevalence of cardiometabolic traits than those with each condition alone.
CONCLUSION—Both fatty liver and VAT are independent correlates of cardiometabolic risk, but the associations are stronger for VAT than for fatty liver.</description><identifier>ISSN: 1079-5642</identifier><identifier>ISSN: 1524-4636</identifier><identifier>EISSN: 1524-4636</identifier><identifier>DOI: 10.1161/ATVBAHA.111.234062</identifier><identifier>PMID: 21885852</identifier><identifier>CODEN: ATVBFA</identifier><language>eng</language><publisher>Philadelphia, PA: American Heart Association, Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Black People - ethnology ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - ethnology ; Cardiovascular Diseases - physiopathology ; Cholesterol, HDL - blood ; Diseases of the aorta ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Fatty Liver - blood ; Fatty Liver - complications ; Fatty Liver - physiopathology ; Female ; Humans ; Intra-Abdominal Fat - physiopathology ; Male ; Medical sciences ; Metabolic Diseases - epidemiology ; Metabolic Diseases - ethnology ; Metabolic Diseases - physiopathology ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - ethnology ; Metabolic Syndrome - physiopathology ; Middle Aged ; Mississippi ; Regression Analysis ; Retrospective Studies ; Risk Factors ; Triglycerides - blood</subject><ispartof>Arteriosclerosis, thrombosis, and vascular biology, 2011-11, Vol.31 (11), p.2715-2722</ispartof><rights>2011 American Heart Association, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4342-9dff0907acea6e8d8305e856c9756733ecfd8b736f7322c1f8d5a52e964328ea3</citedby><cites>FETCH-LOGICAL-c4342-9dff0907acea6e8d8305e856c9756733ecfd8b736f7322c1f8d5a52e964328ea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25285999$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21885852$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jiankang</creatorcontrib><creatorcontrib>Fox, Caroline S</creatorcontrib><creatorcontrib>Hickson, DeMarc</creatorcontrib><creatorcontrib>Bidulescu, Aurelian</creatorcontrib><creatorcontrib>Carr, J Jeffery</creatorcontrib><creatorcontrib>Taylor, Herman A</creatorcontrib><title>Fatty Liver, Abdominal Visceral Fat, and Cardiometabolic Risk Factors: The Jackson Heart Study</title><title>Arteriosclerosis, thrombosis, and vascular biology</title><addtitle>Arterioscler Thromb Vasc Biol</addtitle><description>OBJECTIVE—The goal of this study was to examine whether fatty liver and abdominal visceral adipose tissue (VAT) are jointly associated with cardiometabolic abnormalities.
METHODS AND RESULTS—Black participants were from the Jackson Heart Study (n=2882, 65% women) who underwent computed tomography. Fatty liver was measured by liver attenuation in Hounsfield units (LA), and VAT was quantified volumetrically. Cross-sectional associations between LA, VAT, and cardiometabolic risk factors were assessed using linear and logistic regression, and their joint associations were further examined in 4 subgroupshigh-LA/low-VAT (n=1704), low-LA/low-VAT (n=422), high-LA/high-VAT (n=436), and low-LA/high-VAT (n=320). Both LA and VAT were associated with most cardiometabolic traits (all P<0.0001), which persisted after additional adjustment for each other (LA, P<0.01–0.0001; VAT, P<0.0001). In bootstrap analyses, the regression coefficient of VAT was significantly greater than LA for triglycerides, high-density lipoprotein cholesterol, impaired glucose, and metabolic syndrome (P=0.009–0.0001). The interaction between LA and VAT was significant for high-density lipoprotein cholesterol (P=0.002), impaired glucose (P=0.003), and metabolic syndrome (P=0.04). Among 4 subgroups, participants with higher VAT and lower LA had higher prevalence of cardiometabolic traits than those with each condition alone.
CONCLUSION—Both fatty liver and VAT are independent correlates of cardiometabolic risk, but the associations are stronger for VAT than for fatty liver.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atherosclerosis (general aspects, experimental research)</subject><subject>Biological and medical sciences</subject><subject>Black People - ethnology</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular Diseases - epidemiology</subject><subject>Cardiovascular Diseases - ethnology</subject><subject>Cardiovascular Diseases - physiopathology</subject><subject>Cholesterol, HDL - blood</subject><subject>Diseases of the aorta</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Fatty Liver - blood</subject><subject>Fatty Liver - complications</subject><subject>Fatty Liver - physiopathology</subject><subject>Female</subject><subject>Humans</subject><subject>Intra-Abdominal Fat - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic Diseases - epidemiology</subject><subject>Metabolic Diseases - ethnology</subject><subject>Metabolic Diseases - physiopathology</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - ethnology</subject><subject>Metabolic Syndrome - physiopathology</subject><subject>Middle Aged</subject><subject>Mississippi</subject><subject>Regression Analysis</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Triglycerides - blood</subject><issn>1079-5642</issn><issn>1524-4636</issn><issn>1524-4636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU9v1DAQxSMEoqXwBTggXxCXpvhP7NgcKoVVy7ZaCaldesTyOhPWbBIX22m1376udilw4eQZvd88j-YVxVuCTwgR5GOzvPnczJvckBPKKizos-KQcFqVlWDiea5xrUouKnpQvIrxJ8a4ohS_LA4okZJLTg-L7-cmpS1auDsIx6hZtX5wo-nRjYsWQi6yfozM2KKZCa3zAySz8r2z6MrFTVZt8iF-Qss1oEtjN9GPaA4mJHSdpnb7unjRmT7Cm_17VHw7P1vO5uXi65eLWbMobcUqWqq267DCtbFgBMhWMsxBcmFVzUXNGNiulauaia5mlFrSyZYbTkGJilEJhh0Vpzvf22k1QGthTHl5fRvcYMJWe-P0v8ro1vqHv9PZTlIhssGHvUHwvyaISQ-PF-h7M4KfolY4n1cRgjNJd6QNPsYA3dMvBOvHXPQ-l9wQvcslD737e7-nkd9BZOD9HjDRmr4LZrQu_uE4lVwplTmx4-59nyDETT_dQ9BrMH1a_2-DB1FLp6o</recordid><startdate>201111</startdate><enddate>201111</enddate><creator>Liu, Jiankang</creator><creator>Fox, Caroline S</creator><creator>Hickson, DeMarc</creator><creator>Bidulescu, Aurelian</creator><creator>Carr, J Jeffery</creator><creator>Taylor, Herman A</creator><general>American Heart Association, Inc</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201111</creationdate><title>Fatty Liver, Abdominal Visceral Fat, and Cardiometabolic Risk Factors: The Jackson Heart Study</title><author>Liu, Jiankang ; Fox, Caroline S ; Hickson, DeMarc ; Bidulescu, Aurelian ; Carr, J Jeffery ; Taylor, Herman A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4342-9dff0907acea6e8d8305e856c9756733ecfd8b736f7322c1f8d5a52e964328ea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atherosclerosis (general aspects, experimental research)</topic><topic>Biological and medical sciences</topic><topic>Black People - ethnology</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular Diseases - epidemiology</topic><topic>Cardiovascular Diseases - ethnology</topic><topic>Cardiovascular Diseases - physiopathology</topic><topic>Cholesterol, HDL - blood</topic><topic>Diseases of the aorta</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Fatty Liver - blood</topic><topic>Fatty Liver - complications</topic><topic>Fatty Liver - physiopathology</topic><topic>Female</topic><topic>Humans</topic><topic>Intra-Abdominal Fat - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic Diseases - epidemiology</topic><topic>Metabolic Diseases - ethnology</topic><topic>Metabolic Diseases - physiopathology</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic Syndrome - ethnology</topic><topic>Metabolic Syndrome - physiopathology</topic><topic>Middle Aged</topic><topic>Mississippi</topic><topic>Regression Analysis</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jiankang</creatorcontrib><creatorcontrib>Fox, Caroline S</creatorcontrib><creatorcontrib>Hickson, DeMarc</creatorcontrib><creatorcontrib>Bidulescu, Aurelian</creatorcontrib><creatorcontrib>Carr, J Jeffery</creatorcontrib><creatorcontrib>Taylor, Herman A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jiankang</au><au>Fox, Caroline S</au><au>Hickson, DeMarc</au><au>Bidulescu, Aurelian</au><au>Carr, J Jeffery</au><au>Taylor, Herman A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fatty Liver, Abdominal Visceral Fat, and Cardiometabolic Risk Factors: The Jackson Heart Study</atitle><jtitle>Arteriosclerosis, thrombosis, and vascular biology</jtitle><addtitle>Arterioscler Thromb Vasc Biol</addtitle><date>2011-11</date><risdate>2011</risdate><volume>31</volume><issue>11</issue><spage>2715</spage><epage>2722</epage><pages>2715-2722</pages><issn>1079-5642</issn><issn>1524-4636</issn><eissn>1524-4636</eissn><coden>ATVBFA</coden><abstract>OBJECTIVE—The goal of this study was to examine whether fatty liver and abdominal visceral adipose tissue (VAT) are jointly associated with cardiometabolic abnormalities.
METHODS AND RESULTS—Black participants were from the Jackson Heart Study (n=2882, 65% women) who underwent computed tomography. Fatty liver was measured by liver attenuation in Hounsfield units (LA), and VAT was quantified volumetrically. Cross-sectional associations between LA, VAT, and cardiometabolic risk factors were assessed using linear and logistic regression, and their joint associations were further examined in 4 subgroupshigh-LA/low-VAT (n=1704), low-LA/low-VAT (n=422), high-LA/high-VAT (n=436), and low-LA/high-VAT (n=320). Both LA and VAT were associated with most cardiometabolic traits (all P<0.0001), which persisted after additional adjustment for each other (LA, P<0.01–0.0001; VAT, P<0.0001). In bootstrap analyses, the regression coefficient of VAT was significantly greater than LA for triglycerides, high-density lipoprotein cholesterol, impaired glucose, and metabolic syndrome (P=0.009–0.0001). The interaction between LA and VAT was significant for high-density lipoprotein cholesterol (P=0.002), impaired glucose (P=0.003), and metabolic syndrome (P=0.04). Among 4 subgroups, participants with higher VAT and lower LA had higher prevalence of cardiometabolic traits than those with each condition alone.
CONCLUSION—Both fatty liver and VAT are independent correlates of cardiometabolic risk, but the associations are stronger for VAT than for fatty liver.</abstract><cop>Philadelphia, PA</cop><pub>American Heart Association, Inc</pub><pmid>21885852</pmid><doi>10.1161/ATVBAHA.111.234062</doi><tpages>8</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Atherosclerosis (general aspects, experimental research) Biological and medical sciences Black People - ethnology Blood and lymphatic vessels Cardiology. Vascular system Cardiovascular Diseases - epidemiology Cardiovascular Diseases - ethnology Cardiovascular Diseases - physiopathology Cholesterol, HDL - blood Diseases of the aorta Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Fatty Liver - blood Fatty Liver - complications Fatty Liver - physiopathology Female Humans Intra-Abdominal Fat - physiopathology Male Medical sciences Metabolic Diseases - epidemiology Metabolic Diseases - ethnology Metabolic Diseases - physiopathology Metabolic Syndrome - epidemiology Metabolic Syndrome - ethnology Metabolic Syndrome - physiopathology Middle Aged Mississippi Regression Analysis Retrospective Studies Risk Factors Triglycerides - blood |
| title | Fatty Liver, Abdominal Visceral Fat, and Cardiometabolic Risk Factors: The Jackson Heart Study |
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