The Diversity of Nutritional Status in Cancer: New Insights
Learning Objectives After completing this course, the reader will be able to: Explain how malnutrition (deficit or excess) is used as a decisive factor in treatment of cancer patients. Describe the interactions and influences of overweight/obesity on tumor metabolism and of individualized tumor meta...
Gespeichert in:
| Veröffentlicht in: | The oncologist (Dayton, Ohio) Ohio), 2010-05, Vol.15 (5), p.523-530 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 530 |
|---|---|
| container_issue | 5 |
| container_start_page | 523 |
| container_title | The oncologist (Dayton, Ohio) |
| container_volume | 15 |
| creator | Ramos Chaves, Mariana Boléo‐Tomé, Carolina Monteiro‐Grillo, Isabel Camilo, Maria Ravasco, Paula |
| description | Learning Objectives
After completing this course, the reader will be able to:
Explain how malnutrition (deficit or excess) is used as a decisive factor in treatment of cancer patients.
Describe the interactions and influences of overweight/obesity on tumor metabolism and of individualized tumor metabolism on tumor burden and undernutrition.
Use the association of sarcopenic obesity to predict and manage poorer performance status and decreased survival in cancer patients.
This article is available for continuing medical education credit at CME.TheOncologist.com
Objective.
Nutritional status in cancer has been mostly biased toward undernutrition, an issue now in dispute. We aimed to characterize nutrition status, to analyze associations between nutritional and clinical/cancer‐related variables, and to quantify the relative weights of nutritional and cancer‐related features.
Methods.
The cross‐sectional study included 450 nonselected cancer patients (ages 18–95 years) at referral for radiotherapy. Nutritional status assessment included recent weight changes, body mass index (BMI) categorized by World Health Organization's age/sex criteria, and Patient‐Generated Subjective Global Assessment (PG‐SGA; validated/specific for oncology).
Results.
BMI identified 63% as ≥25 kg/m2 (43% overweight, 20% obese) and 4% as undernourished. PG‐SGA identified 29% as undernourished and 71% as well nourished. Crossing both methods, among the 319 (71%) well‐nourished patients according to PG‐SGA, 75% were overweight/obese and only 25% were well nourished according to BMI. Concordance between BMI and PG‐SGA was evaluated and consistency was confirmed. More aggressive/advanced stage cancers were more prevalent in deficient and excessive nutritional status: in 83% (n = 235/282) of overweight/obese patients by BMI and in 85% (n = 111/131) of undernourished patients by PG‐SGA. Results required adjustment for diagnoses: greater histological aggressiveness was found in overweight/obese prostate and breast cancer; undernutrition was associated with aggressive lung, colorectal, head‐neck, stomach, and esophageal cancers (p < .005). Estimates of effect size revealed that overweight/obesity was associated with advanced stage (24%), aggressive breast (10%), and prostate (9%) cancers, whereas undernutrition was associated with more aggressive lung (6%), colorectal (6%), and head‐neck (6%) cancers; in both instances, age and longer disease duration were of significance.
Conclusion.
Undernutri |
| doi_str_mv | 10.1634/theoncologist.2009-0283 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3227982</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>733556260</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5363-a9cb3b3640cad5ca43816d525036ecd4c351186480dadbc9485bfdcf711861bd3</originalsourceid><addsrcrecordid>eNqNkMtOwzAQRS0EglL4BciOVcD2xHmAQELhVQm1C0BiZzmO0xilMdhOUf-eRIUKdqxmNHPvndFB6JjgUxJDdOZrZVppGjPXzp9SjLMQ0xS20IiwKAujDL9u9z1OIUwIy_bQvnNvGPct0F20RzFkjDE6QhfPtQpu9FJZp_0qMFUw7bzVXptWNMGTF75zgW6DXLRS2fNgqj6DSev0vPbuAO1UonHq8LuO0cvd7XP-ED7O7if59WMoGcQQikwWUEAcYSlKJkUEKYlLRhmGWMkyksAISeMoxaUoC5lFKSuqUlbJMCVFCWN0tc5974qFKqVqvRUNf7d6IeyKG6H5302raz43Sw6UJllK-4CT7wBrPjrlPF9oJ1XTiFaZzvEEgLGYxrhXJmultMY5q6rNFYL5QJ7_Ic8H8nwg3zuPfj-58f2g7gWXa8GnbtTqv7l8Ns1nuLfDF3w2mNg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>733556260</pqid></control><display><type>article</type><title>The Diversity of Nutritional Status in Cancer: New Insights</title><source>PubMed (Medline)</source><source>MEDLINE</source><source>EZB Electronic Journals Library</source><source>Wiley Blackwell Journals</source><source>Oxford Open Access Journals</source><creator>Ramos Chaves, Mariana ; Boléo‐Tomé, Carolina ; Monteiro‐Grillo, Isabel ; Camilo, Maria ; Ravasco, Paula</creator><creatorcontrib>Ramos Chaves, Mariana ; Boléo‐Tomé, Carolina ; Monteiro‐Grillo, Isabel ; Camilo, Maria ; Ravasco, Paula</creatorcontrib><description>Learning Objectives
After completing this course, the reader will be able to:
Explain how malnutrition (deficit or excess) is used as a decisive factor in treatment of cancer patients.
Describe the interactions and influences of overweight/obesity on tumor metabolism and of individualized tumor metabolism on tumor burden and undernutrition.
Use the association of sarcopenic obesity to predict and manage poorer performance status and decreased survival in cancer patients.
This article is available for continuing medical education credit at CME.TheOncologist.com
Objective.
Nutritional status in cancer has been mostly biased toward undernutrition, an issue now in dispute. We aimed to characterize nutrition status, to analyze associations between nutritional and clinical/cancer‐related variables, and to quantify the relative weights of nutritional and cancer‐related features.
Methods.
The cross‐sectional study included 450 nonselected cancer patients (ages 18–95 years) at referral for radiotherapy. Nutritional status assessment included recent weight changes, body mass index (BMI) categorized by World Health Organization's age/sex criteria, and Patient‐Generated Subjective Global Assessment (PG‐SGA; validated/specific for oncology).
Results.
BMI identified 63% as ≥25 kg/m2 (43% overweight, 20% obese) and 4% as undernourished. PG‐SGA identified 29% as undernourished and 71% as well nourished. Crossing both methods, among the 319 (71%) well‐nourished patients according to PG‐SGA, 75% were overweight/obese and only 25% were well nourished according to BMI. Concordance between BMI and PG‐SGA was evaluated and consistency was confirmed. More aggressive/advanced stage cancers were more prevalent in deficient and excessive nutritional status: in 83% (n = 235/282) of overweight/obese patients by BMI and in 85% (n = 111/131) of undernourished patients by PG‐SGA. Results required adjustment for diagnoses: greater histological aggressiveness was found in overweight/obese prostate and breast cancer; undernutrition was associated with aggressive lung, colorectal, head‐neck, stomach, and esophageal cancers (p < .005). Estimates of effect size revealed that overweight/obesity was associated with advanced stage (24%), aggressive breast (10%), and prostate (9%) cancers, whereas undernutrition was associated with more aggressive lung (6%), colorectal (6%), and head‐neck (6%) cancers; in both instances, age and longer disease duration were of significance.
Conclusion.
Undernutrition and overweight/obesity have distinct implications and bear a negative prognosis in cancer. This study provides novel data on the prevalence of overweight/obesity and undernutrition in cancer patients and their potential role in cancer histological behavior.
This paper provides novel data on the prevalence of overweight/obesity and undernutrition in cancer patients and shows that there is a likely relation among nutritional status, disease aggressiveness, and consequent association with prognosis.</description><identifier>ISSN: 1083-7159</identifier><identifier>EISSN: 1549-490X</identifier><identifier>DOI: 10.1634/theoncologist.2009-0283</identifier><identifier>PMID: 20395552</identifier><language>eng</language><publisher>Durham, NC, USA: AlphaMed Press</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Body Mass Index ; Cancer ; Cross-Sectional Studies ; Female ; Histological aggressiveness ; Humans ; Male ; Malnutrition - epidemiology ; Middle Aged ; Neoplasms - physiopathology ; Nutritional Status ; Obesity - epidemiology ; Overweight - epidemiology ; Patient‐Generated Subjective Global Assessment ; Portugal - epidemiology ; Prevalence ; Symptom Management and Supportive Care ; Young Adult</subject><ispartof>The oncologist (Dayton, Ohio), 2010-05, Vol.15 (5), p.523-530</ispartof><rights>2010 AlphaMed Press</rights><rights>AlphaMed Press 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5363-a9cb3b3640cad5ca43816d525036ecd4c351186480dadbc9485bfdcf711861bd3</citedby><cites>FETCH-LOGICAL-c5363-a9cb3b3640cad5ca43816d525036ecd4c351186480dadbc9485bfdcf711861bd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227982/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC3227982/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20395552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ramos Chaves, Mariana</creatorcontrib><creatorcontrib>Boléo‐Tomé, Carolina</creatorcontrib><creatorcontrib>Monteiro‐Grillo, Isabel</creatorcontrib><creatorcontrib>Camilo, Maria</creatorcontrib><creatorcontrib>Ravasco, Paula</creatorcontrib><title>The Diversity of Nutritional Status in Cancer: New Insights</title><title>The oncologist (Dayton, Ohio)</title><addtitle>Oncologist</addtitle><description>Learning Objectives
After completing this course, the reader will be able to:
Explain how malnutrition (deficit or excess) is used as a decisive factor in treatment of cancer patients.
Describe the interactions and influences of overweight/obesity on tumor metabolism and of individualized tumor metabolism on tumor burden and undernutrition.
Use the association of sarcopenic obesity to predict and manage poorer performance status and decreased survival in cancer patients.
This article is available for continuing medical education credit at CME.TheOncologist.com
Objective.
Nutritional status in cancer has been mostly biased toward undernutrition, an issue now in dispute. We aimed to characterize nutrition status, to analyze associations between nutritional and clinical/cancer‐related variables, and to quantify the relative weights of nutritional and cancer‐related features.
Methods.
The cross‐sectional study included 450 nonselected cancer patients (ages 18–95 years) at referral for radiotherapy. Nutritional status assessment included recent weight changes, body mass index (BMI) categorized by World Health Organization's age/sex criteria, and Patient‐Generated Subjective Global Assessment (PG‐SGA; validated/specific for oncology).
Results.
BMI identified 63% as ≥25 kg/m2 (43% overweight, 20% obese) and 4% as undernourished. PG‐SGA identified 29% as undernourished and 71% as well nourished. Crossing both methods, among the 319 (71%) well‐nourished patients according to PG‐SGA, 75% were overweight/obese and only 25% were well nourished according to BMI. Concordance between BMI and PG‐SGA was evaluated and consistency was confirmed. More aggressive/advanced stage cancers were more prevalent in deficient and excessive nutritional status: in 83% (n = 235/282) of overweight/obese patients by BMI and in 85% (n = 111/131) of undernourished patients by PG‐SGA. Results required adjustment for diagnoses: greater histological aggressiveness was found in overweight/obese prostate and breast cancer; undernutrition was associated with aggressive lung, colorectal, head‐neck, stomach, and esophageal cancers (p < .005). Estimates of effect size revealed that overweight/obesity was associated with advanced stage (24%), aggressive breast (10%), and prostate (9%) cancers, whereas undernutrition was associated with more aggressive lung (6%), colorectal (6%), and head‐neck (6%) cancers; in both instances, age and longer disease duration were of significance.
Conclusion.
Undernutrition and overweight/obesity have distinct implications and bear a negative prognosis in cancer. This study provides novel data on the prevalence of overweight/obesity and undernutrition in cancer patients and their potential role in cancer histological behavior.
This paper provides novel data on the prevalence of overweight/obesity and undernutrition in cancer patients and shows that there is a likely relation among nutritional status, disease aggressiveness, and consequent association with prognosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Body Mass Index</subject><subject>Cancer</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Histological aggressiveness</subject><subject>Humans</subject><subject>Male</subject><subject>Malnutrition - epidemiology</subject><subject>Middle Aged</subject><subject>Neoplasms - physiopathology</subject><subject>Nutritional Status</subject><subject>Obesity - epidemiology</subject><subject>Overweight - epidemiology</subject><subject>Patient‐Generated Subjective Global Assessment</subject><subject>Portugal - epidemiology</subject><subject>Prevalence</subject><subject>Symptom Management and Supportive Care</subject><subject>Young Adult</subject><issn>1083-7159</issn><issn>1549-490X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EglL4BciOVcD2xHmAQELhVQm1C0BiZzmO0xilMdhOUf-eRIUKdqxmNHPvndFB6JjgUxJDdOZrZVppGjPXzp9SjLMQ0xS20IiwKAujDL9u9z1OIUwIy_bQvnNvGPct0F20RzFkjDE6QhfPtQpu9FJZp_0qMFUw7bzVXptWNMGTF75zgW6DXLRS2fNgqj6DSev0vPbuAO1UonHq8LuO0cvd7XP-ED7O7if59WMoGcQQikwWUEAcYSlKJkUEKYlLRhmGWMkyksAISeMoxaUoC5lFKSuqUlbJMCVFCWN0tc5974qFKqVqvRUNf7d6IeyKG6H5302raz43Sw6UJllK-4CT7wBrPjrlPF9oJ1XTiFaZzvEEgLGYxrhXJmultMY5q6rNFYL5QJ7_Ic8H8nwg3zuPfj-58f2g7gWXa8GnbtTqv7l8Ns1nuLfDF3w2mNg</recordid><startdate>201005</startdate><enddate>201005</enddate><creator>Ramos Chaves, Mariana</creator><creator>Boléo‐Tomé, Carolina</creator><creator>Monteiro‐Grillo, Isabel</creator><creator>Camilo, Maria</creator><creator>Ravasco, Paula</creator><general>AlphaMed Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201005</creationdate><title>The Diversity of Nutritional Status in Cancer: New Insights</title><author>Ramos Chaves, Mariana ; Boléo‐Tomé, Carolina ; Monteiro‐Grillo, Isabel ; Camilo, Maria ; Ravasco, Paula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5363-a9cb3b3640cad5ca43816d525036ecd4c351186480dadbc9485bfdcf711861bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Body Mass Index</topic><topic>Cancer</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Histological aggressiveness</topic><topic>Humans</topic><topic>Male</topic><topic>Malnutrition - epidemiology</topic><topic>Middle Aged</topic><topic>Neoplasms - physiopathology</topic><topic>Nutritional Status</topic><topic>Obesity - epidemiology</topic><topic>Overweight - epidemiology</topic><topic>Patient‐Generated Subjective Global Assessment</topic><topic>Portugal - epidemiology</topic><topic>Prevalence</topic><topic>Symptom Management and Supportive Care</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ramos Chaves, Mariana</creatorcontrib><creatorcontrib>Boléo‐Tomé, Carolina</creatorcontrib><creatorcontrib>Monteiro‐Grillo, Isabel</creatorcontrib><creatorcontrib>Camilo, Maria</creatorcontrib><creatorcontrib>Ravasco, Paula</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The oncologist (Dayton, Ohio)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ramos Chaves, Mariana</au><au>Boléo‐Tomé, Carolina</au><au>Monteiro‐Grillo, Isabel</au><au>Camilo, Maria</au><au>Ravasco, Paula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Diversity of Nutritional Status in Cancer: New Insights</atitle><jtitle>The oncologist (Dayton, Ohio)</jtitle><addtitle>Oncologist</addtitle><date>2010-05</date><risdate>2010</risdate><volume>15</volume><issue>5</issue><spage>523</spage><epage>530</epage><pages>523-530</pages><issn>1083-7159</issn><eissn>1549-490X</eissn><abstract>Learning Objectives
After completing this course, the reader will be able to:
Explain how malnutrition (deficit or excess) is used as a decisive factor in treatment of cancer patients.
Describe the interactions and influences of overweight/obesity on tumor metabolism and of individualized tumor metabolism on tumor burden and undernutrition.
Use the association of sarcopenic obesity to predict and manage poorer performance status and decreased survival in cancer patients.
This article is available for continuing medical education credit at CME.TheOncologist.com
Objective.
Nutritional status in cancer has been mostly biased toward undernutrition, an issue now in dispute. We aimed to characterize nutrition status, to analyze associations between nutritional and clinical/cancer‐related variables, and to quantify the relative weights of nutritional and cancer‐related features.
Methods.
The cross‐sectional study included 450 nonselected cancer patients (ages 18–95 years) at referral for radiotherapy. Nutritional status assessment included recent weight changes, body mass index (BMI) categorized by World Health Organization's age/sex criteria, and Patient‐Generated Subjective Global Assessment (PG‐SGA; validated/specific for oncology).
Results.
BMI identified 63% as ≥25 kg/m2 (43% overweight, 20% obese) and 4% as undernourished. PG‐SGA identified 29% as undernourished and 71% as well nourished. Crossing both methods, among the 319 (71%) well‐nourished patients according to PG‐SGA, 75% were overweight/obese and only 25% were well nourished according to BMI. Concordance between BMI and PG‐SGA was evaluated and consistency was confirmed. More aggressive/advanced stage cancers were more prevalent in deficient and excessive nutritional status: in 83% (n = 235/282) of overweight/obese patients by BMI and in 85% (n = 111/131) of undernourished patients by PG‐SGA. Results required adjustment for diagnoses: greater histological aggressiveness was found in overweight/obese prostate and breast cancer; undernutrition was associated with aggressive lung, colorectal, head‐neck, stomach, and esophageal cancers (p < .005). Estimates of effect size revealed that overweight/obesity was associated with advanced stage (24%), aggressive breast (10%), and prostate (9%) cancers, whereas undernutrition was associated with more aggressive lung (6%), colorectal (6%), and head‐neck (6%) cancers; in both instances, age and longer disease duration were of significance.
Conclusion.
Undernutrition and overweight/obesity have distinct implications and bear a negative prognosis in cancer. This study provides novel data on the prevalence of overweight/obesity and undernutrition in cancer patients and their potential role in cancer histological behavior.
This paper provides novel data on the prevalence of overweight/obesity and undernutrition in cancer patients and shows that there is a likely relation among nutritional status, disease aggressiveness, and consequent association with prognosis.</abstract><cop>Durham, NC, USA</cop><pub>AlphaMed Press</pub><pmid>20395552</pmid><doi>10.1634/theoncologist.2009-0283</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1083-7159 |
| ispartof | The oncologist (Dayton, Ohio), 2010-05, Vol.15 (5), p.523-530 |
| issn | 1083-7159 1549-490X |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3227982 |
| source | PubMed (Medline); MEDLINE; EZB Electronic Journals Library; Wiley Blackwell Journals; Oxford Open Access Journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Body Mass Index Cancer Cross-Sectional Studies Female Histological aggressiveness Humans Male Malnutrition - epidemiology Middle Aged Neoplasms - physiopathology Nutritional Status Obesity - epidemiology Overweight - epidemiology Patient‐Generated Subjective Global Assessment Portugal - epidemiology Prevalence Symptom Management and Supportive Care Young Adult |
| title | The Diversity of Nutritional Status in Cancer: New Insights |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T09%3A25%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Diversity%20of%20Nutritional%20Status%20in%20Cancer:%20New%20Insights&rft.jtitle=The%20oncologist%20(Dayton,%20Ohio)&rft.au=Ramos%20Chaves,%20Mariana&rft.date=2010-05&rft.volume=15&rft.issue=5&rft.spage=523&rft.epage=530&rft.pages=523-530&rft.issn=1083-7159&rft.eissn=1549-490X&rft_id=info:doi/10.1634/theoncologist.2009-0283&rft_dat=%3Cproquest_pubme%3E733556260%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=733556260&rft_id=info:pmid/20395552&rfr_iscdi=true |