Explanting Is an Ex Vivo Model of Renal Epithelial-Mesenchymal Transition

Recognised by their de novo expression of alpha-smooth muscle actin (SMA), recruitment of myofibroblasts is key to the pathogenesis of fibrosis in chronic kidney disease. Increasingly, we realise that epithelial-mesenchymal transition (EMT) may be an important source of these cells. In this study we...

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Veröffentlicht in:	BioMed research international 2011-01, Vol.2011 (2011), p.1-7
Hauptverfasser:	Kelynack, Kristen J., Winbanks, Catherine E., Hewitson, Tim D., Becker, Gavin J., Pouniotis, Dodie, Darby, Ian A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers - analysis Cell Culture Techniques Cell Differentiation - physiology Cell Proliferation Endothelial Cells - cytology Endothelial Cells - metabolism Epithelial Cells - cytology Epithelial Cells - metabolism Epithelial-Mesenchymal Transition - physiology Immunochemistry - methods Kidney - cytology Kidney Tubules, Proximal - metabolism Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Myofibroblasts - cytology Myofibroblasts - metabolism Phenotype Rats Rats, Sprague-Dawley Staining and Labeling - methods
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