High-throughput semiquantitative analysis of insertional mutations in heterogeneous tumors

Retroviral and transposon-based insertional mutagenesis (IM) screens are widely used for cancer gene discovery in mice. Exploiting the full potential of IM screens requires methods for high-throughput sequencing and mapping of transposon and retroviral insertion sites. Current protocols are based on...

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Veröffentlicht in:	Genome research 2011-12, Vol.21 (12), p.2181-2189
Hauptverfasser:	Koudijs, Marco J, Klijn, Christiaan, van der Weyden, Louise, Kool, Jaap, ten Hoeve, Jelle, Sie, Daoud, Prasetyanti, Pramudita R, Schut, Eva, Kas, Sjors, Whipp, Theodore, Cuppen, Edwin, Wessels, Lodewyk, Adams, David J, Jonkers, Jos
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Databases, Genetic DNA Mutational Analysis - methods DNA, Neoplasm - genetics Mammary Tumor Virus, Mouse Method Mice Mouse mammary tumor virus Mutagenesis, Insertional Retroviridae Infections - genetics Tumor Virus Infections - genetics
Online-Zugang:	Volltext
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