Mouse strain-dependent caspase activation during acetaminophen hepatotoxicity does not result in apoptosis or modulation of inflammation

The mechanisms of acetaminophen (APAP)-mediated hepatic oncotic necrosis have been extensively characterized. However, it was recently demonstrated that fed CD-1 mice have a transient caspase activation which initiates apoptosis. To evaluate these findings in more detail, outbred (Swiss Webster, SW)...

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Veröffentlicht in:	Toxicology and applied pharmacology 2011-12, Vol.257 (3), p.449-458
Hauptverfasser:	Williams, C. David, Koerner, Michael R., Lampe, Jed N., Farhood, Anwar, Jaeschke, Hartmut
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Acetaminophen Acetaminophen - toxicity Animals APOPTOSIS Apoptosis - drug effects ATP Biological and medical sciences Caspase 3 - metabolism Caspases Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - pathology DNA DNA fragmentation Endotoxins - toxicity Fasting Galactosamine - toxicity GLUTATHIONE Glutathione - drug effects Glutathione - metabolism Hepatocytes - drug effects Hepatocytes - pathology Hepatotoxicity INFLAMMATION Inflammation - chemically induced Inflammation - pathology INJURIES LIVER LIVER CELLS Male Medical sciences Mice Mice, Inbred C57BL MORPHOLOGY NECROSIS NEUTROPHILS Neutrophils - metabolism Species Specificity Toxicology
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