Patient-derived endothelial progenitor cells improve vascular graft patency in a rodent model

Late outgrowth endothelial progenitor cells (EPCs) derived from the peripheral blood of patients with significant coronary artery disease were sodded into the lumens of small diameter expanded polytetrafluoroethylene (ePTFE) vascular grafts. Grafts (1mm inner diameter) were denucleated and sodded ei...

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Veröffentlicht in:	Acta biomaterialia 2012-01, Vol.8 (1), p.201-208
Hauptverfasser:	Stroncek, J.D., Ren, L.C., Klitzman, B., Reichert, W.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals arteries blood Blood Vessel Prosthesis Cells, Cultured Coronary artery disease Endothelial Cells - cytology Endothelial Cells - physiology Endothelial progenitor cells Endothelium, Vascular - cytology ePTFE genes Humans hyperplasia Hyperplasia - pathology in vivo studies Male patients polytetrafluoroethylene Protein C - metabolism Rats Rats, Nude stem cells Stem Cells - cytology Stem Cells - physiology Synthetic vascular graft Thrombomodulin thrombosis Tunica Intima - pathology Vascular Grafting - methods Vascular Patency
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