The Environmental Polymorphism Registry: A Unique Resource that Facilitates Translational Research of Environmental Disease
Background: Dissecting complex disease has become more feasible because of the availability of large-scale DNA resources and advances in high-throughput genomic technology. Although these tools help scientists identify potential susceptibility loci, subjects with relevant genotypes are needed for cl...
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| Veröffentlicht in: | Environmental health perspectives 2011-11, Vol.119 (11), p.1523-1527 |
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| creator | Chulada, Patricia C. Vainorius, Enrikas Garantziotis, Stavros Burch, Lauranell H. Blackshear, Perry J. Zeldin, Darryl C. |
| description | Background: Dissecting complex disease has become more feasible because of the availability of large-scale DNA resources and advances in high-throughput genomic technology. Although these tools help scientists identify potential susceptibility loci, subjects with relevant genotypes are needed for clinical phenotyping and toxicity studies. Objective: We have developed a resource of subjects and their DNA to use for translational research of environmental disease. Methods: More than 15,000 individuals of diverse sex, age, race, and ethnicity were recruited from North Carolina. DNA was isolated from their blood and coded with personal identification numbers linked to their identities. This linked resource of subjects and their DNA—the Environmental Polymorphism Registry (EPR)—allows scientists to screen for individuals with genotypes of interest and invite them to participate in follow-up studies. Discussion: The EPR is a phenotype-by-genotype resource designed to facilitate translational studies of environmental disease. Based on their genotypes, subjects are invited to participate at all levels of research, from basic laboratory ex vivo cell phenotyping experiments that require viable tissue to in vivo observational studies and clinical trials. Here we report on progress of the EPR since 2008. We also describe a major effort at the National Institute of Environmental Health Sciences (NIEHS) to investigate susceptibility loci in 87 environmental response genes and gene × environment interactions using EPR resources. Conclusion: The EPR is a unique and novel resource and is ideal for genotype-driven translational research of environmental disease. We expect that it will serve as a model for future resources. Such tools help scientists attain their ultimate goals: to identify at-risk populations and develop strategies for preventing and treating human disease. |
| doi_str_mv | 10.1289/ehp.1003348 |
| format | Article |
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Although these tools help scientists identify potential susceptibility loci, subjects with relevant genotypes are needed for clinical phenotyping and toxicity studies. Objective: We have developed a resource of subjects and their DNA to use for translational research of environmental disease. Methods: More than 15,000 individuals of diverse sex, age, race, and ethnicity were recruited from North Carolina. DNA was isolated from their blood and coded with personal identification numbers linked to their identities. This linked resource of subjects and their DNA—the Environmental Polymorphism Registry (EPR)—allows scientists to screen for individuals with genotypes of interest and invite them to participate in follow-up studies. Discussion: The EPR is a phenotype-by-genotype resource designed to facilitate translational studies of environmental disease. Based on their genotypes, subjects are invited to participate at all levels of research, from basic laboratory ex vivo cell phenotyping experiments that require viable tissue to in vivo observational studies and clinical trials. Here we report on progress of the EPR since 2008. We also describe a major effort at the National Institute of Environmental Health Sciences (NIEHS) to investigate susceptibility loci in 87 environmental response genes and gene × environment interactions using EPR resources. Conclusion: The EPR is a unique and novel resource and is ideal for genotype-driven translational research of environmental disease. We expect that it will serve as a model for future resources. Such tools help scientists attain their ultimate goals: to identify at-risk populations and develop strategies for preventing and treating human disease.</description><identifier>ISSN: 0091-6765</identifier><identifier>EISSN: 1552-9924</identifier><identifier>DOI: 10.1289/ehp.1003348</identifier><identifier>PMID: 21659040</identifier><language>eng</language><publisher>United States: National Institute of Environmental Health Sciences</publisher><subject>Adolescent ; Adult ; Aged ; Commentaries ; Disease susceptibility ; DNA ; DNA - genetics ; Environmental disorders ; Environmental Exposure - adverse effects ; Environmental health ; Environmental Monitoring - statistics & numerical data ; Environmentally induced diseases ; Epidemiological Monitoring ; Ethnicity ; Female ; Follow up studies ; Genetic loci ; Genetic polymorphisms ; Genetic Predisposition to Disease - epidemiology ; Genetic research ; Genotype ; Genotypes ; Humans ; Male ; Middle Aged ; Natural resources ; North Carolina - epidemiology ; Phenotype ; Polymorphism, Genetic ; Registries ; Research facilities ; Translational Medical Research</subject><ispartof>Environmental health perspectives, 2011-11, Vol.119 (11), p.1523-1527</ispartof><rights>COPYRIGHT 2011 National Institute of Environmental Health Sciences</rights><rights>Copyright National Institute of Environmental Health Sciences Nov 2011</rights><rights>2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c633t-913d556b8b4a93f7ef1a4110b0c60571074d9d3f5ee273c4963f468f48b3e4bf3</citedby><cites>FETCH-LOGICAL-c633t-913d556b8b4a93f7ef1a4110b0c60571074d9d3f5ee273c4963f468f48b3e4bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/41263253$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/41263253$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,723,776,780,799,860,881,27901,27902,53766,53768,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21659040$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chulada, Patricia C.</creatorcontrib><creatorcontrib>Vainorius, Enrikas</creatorcontrib><creatorcontrib>Garantziotis, Stavros</creatorcontrib><creatorcontrib>Burch, Lauranell H.</creatorcontrib><creatorcontrib>Blackshear, Perry J.</creatorcontrib><creatorcontrib>Zeldin, Darryl C.</creatorcontrib><title>The Environmental Polymorphism Registry: A Unique Resource that Facilitates Translational Research of Environmental Disease</title><title>Environmental health perspectives</title><addtitle>Environ Health Perspect</addtitle><description>Background: Dissecting complex disease has become more feasible because of the availability of large-scale DNA resources and advances in high-throughput genomic technology. Although these tools help scientists identify potential susceptibility loci, subjects with relevant genotypes are needed for clinical phenotyping and toxicity studies. Objective: We have developed a resource of subjects and their DNA to use for translational research of environmental disease. Methods: More than 15,000 individuals of diverse sex, age, race, and ethnicity were recruited from North Carolina. DNA was isolated from their blood and coded with personal identification numbers linked to their identities. This linked resource of subjects and their DNA—the Environmental Polymorphism Registry (EPR)—allows scientists to screen for individuals with genotypes of interest and invite them to participate in follow-up studies. Discussion: The EPR is a phenotype-by-genotype resource designed to facilitate translational studies of environmental disease. Based on their genotypes, subjects are invited to participate at all levels of research, from basic laboratory ex vivo cell phenotyping experiments that require viable tissue to in vivo observational studies and clinical trials. Here we report on progress of the EPR since 2008. We also describe a major effort at the National Institute of Environmental Health Sciences (NIEHS) to investigate susceptibility loci in 87 environmental response genes and gene × environment interactions using EPR resources. Conclusion: The EPR is a unique and novel resource and is ideal for genotype-driven translational research of environmental disease. We expect that it will serve as a model for future resources. Such tools help scientists attain their ultimate goals: to identify at-risk populations and develop strategies for preventing and treating human disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Commentaries</subject><subject>Disease susceptibility</subject><subject>DNA</subject><subject>DNA - genetics</subject><subject>Environmental disorders</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental health</subject><subject>Environmental Monitoring - statistics & numerical data</subject><subject>Environmentally induced diseases</subject><subject>Epidemiological Monitoring</subject><subject>Ethnicity</subject><subject>Female</subject><subject>Follow up studies</subject><subject>Genetic loci</subject><subject>Genetic polymorphisms</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>Genetic 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Perspect</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>119</volume><issue>11</issue><spage>1523</spage><epage>1527</epage><pages>1523-1527</pages><issn>0091-6765</issn><eissn>1552-9924</eissn><abstract>Background: Dissecting complex disease has become more feasible because of the availability of large-scale DNA resources and advances in high-throughput genomic technology. Although these tools help scientists identify potential susceptibility loci, subjects with relevant genotypes are needed for clinical phenotyping and toxicity studies. Objective: We have developed a resource of subjects and their DNA to use for translational research of environmental disease. Methods: More than 15,000 individuals of diverse sex, age, race, and ethnicity were recruited from North Carolina. DNA was isolated from their blood and coded with personal identification numbers linked to their identities. This linked resource of subjects and their DNA—the Environmental Polymorphism Registry (EPR)—allows scientists to screen for individuals with genotypes of interest and invite them to participate in follow-up studies. Discussion: The EPR is a phenotype-by-genotype resource designed to facilitate translational studies of environmental disease. Based on their genotypes, subjects are invited to participate at all levels of research, from basic laboratory ex vivo cell phenotyping experiments that require viable tissue to in vivo observational studies and clinical trials. Here we report on progress of the EPR since 2008. We also describe a major effort at the National Institute of Environmental Health Sciences (NIEHS) to investigate susceptibility loci in 87 environmental response genes and gene × environment interactions using EPR resources. Conclusion: The EPR is a unique and novel resource and is ideal for genotype-driven translational research of environmental disease. We expect that it will serve as a model for future resources. Such tools help scientists attain their ultimate goals: to identify at-risk populations and develop strategies for preventing and treating human disease.</abstract><cop>United States</cop><pub>National Institute of Environmental Health Sciences</pub><pmid>21659040</pmid><doi>10.1289/ehp.1003348</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Commentaries Disease susceptibility DNA DNA - genetics Environmental disorders Environmental Exposure - adverse effects Environmental health Environmental Monitoring - statistics & numerical data Environmentally induced diseases Epidemiological Monitoring Ethnicity Female Follow up studies Genetic loci Genetic polymorphisms Genetic Predisposition to Disease - epidemiology Genetic research Genotype Genotypes Humans Male Middle Aged Natural resources North Carolina - epidemiology Phenotype Polymorphism, Genetic Registries Research facilities Translational Medical Research |
| title | The Environmental Polymorphism Registry: A Unique Resource that Facilitates Translational Research of Environmental Disease |
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