Distinct structural domains within C19ORF5 support association with stabilized microtubules and mitochondrial aggregation and genome destruction

C19ORF5 is a sequence homologue of microtubule-associated proteins MAP1A/MAP1B of unknown function, except for its association with mitochondria-associated proteins and the paclitaxel-like microtubule stabilizer and candidate tumor suppressor RASSF1A. Here, we show that when overexpressed in mammali...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2005-05, Vol.65 (10), p.4191-4201
Hauptverfasser:	LEYUAN LIU, VO, Amy, GUOQIN LIU, MCKEEHAN, Wallace L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antineoplastic agents Biological and medical sciences Chlorocebus aethiops COS Cells Cytosol - metabolism DNA - genetics DNA - metabolism Genome Humans Liver - drug effects Liver - metabolism Medical sciences Microtubule-Associated Proteins - genetics Microtubule-Associated Proteins - metabolism Microtubules - metabolism Mitochondria - metabolism Molecular Sequence Data Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Paclitaxel - pharmacology Pharmacology. Drug treatments Protein Structure, Tertiary Sequence Homology, Amino Acid Transfection Tubulin - metabolism Tumors
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