Androgen Receptor Gene Expression in Prostate Cancer Is Directly Suppressed by the Androgen Receptor Through Recruitment of Lysine-Specific Demethylase 1

Androgen receptor (AR) is reactivated in castration-resistant prostate cancer (CRPC) through mechanisms including marked increases in AR gene expression. We identify an enhancer in the AR second intron contributing to increased AR expression at low androgen levels in CRPC. Moreover, at increased and...

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Veröffentlicht in:	Cancer cell 2011-10, Vol.20 (4), p.457-471
Hauptverfasser:	Cai, Changmeng, He, Housheng Hansen, Chen, Sen, Coleman, Ilsa, Wang, Hongyun, Fang, Zi, Chen, Shaoyong, Nelson, Peter S., Liu, X. Shirley, Brown, Myles, Balk, Steven P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Androgens - pharmacology Cell Line, Tumor Enhancer Elements, Genetic Gene Expression Regulation, Neoplastic Histone Demethylases - metabolism Histones - metabolism Humans Male Methylation Prostatic Neoplasms - enzymology Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Receptors, Androgen - genetics RNA, Messenger - metabolism
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