A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C)

Tyrosine kinase 2 (Tyk2) is an integral part of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway which relays intracellular signals of various cytokines. Tyk2 crucially contributes to host defense mechanisms against microbial pathogens and to tumor surveillance bu...

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Veröffentlicht in:	Journal of proteomics 2011-11, Vol.74 (12), p.2866-2880
Hauptverfasser:	Grunert, Tom, Leitner, Nicole R., Marchetti-Deschmann, Martina, Miller, Ingrid, Wallner, Barbara, Radwan, Marta, Vogl, Claus, Kolbe, Thomas, Kratky, Dagmar, Gemeiner, Manfred, Allmaier, Günter, Müller, Mathias, Strobl, Birgit
Format:	Artikel
Sprache:	eng
Schlagworte:	2D-DIGE Animals Biological and medical sciences biosynthesis carbohydrate metabolism Carbohydrate Metabolism - drug effects Carbohydrate Metabolism - genetics Carbohydrate Metabolism - immunology cell-mediated immunity cytokines cytology defense mechanisms Diverse techniques double-stranded RNA drug effects Fundamental and applied biological sciences. Psychology gene expression regulation Gene Expression Regulation - drug effects Gene Expression Regulation - genetics Gene Expression Regulation - immunology genetics glucose Glucose - genetics Glucose - immunology Glucose - metabolism immune response Immunity Immunity, Innate Immunity, Innate - drug effects Immunity, Innate - genetics Immunity, Innate - immunology immunology innate immunity Interferon Inducers Interferon Inducers - pharmacology lipid metabolism Lipid Metabolism - drug effects Lipid Metabolism - genetics Lipid Metabolism - immunology long-chain-fatty-acid-CoA ligase Macrophages Macrophages - cytology Macrophages - immunology Macrophages - metabolism Mass spectrometry Metabolism metabolites Mice Mice, Knockout Molecular and cellular biology monitoring pathogens pharmacology Poly I-C Poly I-C - pharmacology protein synthesis proteins proteome Proteome - biosynthesis Proteome - genetics Proteome - immunology transcription factors triose-phosphate isomerase TYK2 Kinase TYK2 Kinase - genetics TYK2 Kinase - immunology TYK2 Kinase - metabolism tyrosine
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