Epidermal growth factor receptor mutation in combination with expression of MIG6 alters gefitinib sensitivity

Epidermal growth factor receptor (EGFR) signaling plays an important role in the regulation of cell proliferation, survival, metastasis, and invasion in various tumors. Earlier studies showed that the EGFR is frequently overexpressed in non-small-cell lung cancer (NSCLC) and EGFR mutations at specif...

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Veröffentlicht in:	BMC systems biology 2011-02, Vol.5 (29), p.29-29, Article 29
Hauptverfasser:	Naruo, Yoshimi, Nagashima, Takeshi, Ushikoshi-Nakayama, Ryoko, Saeki, Yuko, Nakakuki, Takashi, Naka, Takashi, Tanaka, Hiroshi, Tsai, Shih-Feng, Okada-Hatakeyama, Mariko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Analysis Blotting, Western Care and treatment Cell Line, Tumor Cellular signal transduction Complications and side effects Computational Biology DNA Primers - genetics Dosage and administration Dose-response relationship (Biochemistry) Electrophoresis, Polyacrylamide Gel Epidermal growth factors ErbB Receptors - antagonists & inhibitors ErbB Receptors - genetics ErbB Receptors - physiology Gefitinib Genetic aspects Growth hormones Health aspects Humans Influence Information science Kinases Lung cancer Medical research Models, Biological Mutation Mutation - genetics Non-small cell lung cancer Phosphorylation Physiological aspects Proteins Quinazolines - pharmacology Signal Transduction - physiology Studies Time Factors Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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