A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI
Evidence that physical activity (PA) modulates the association between the fat mass and obesity-associated gene (FTO) and BMI is emerging; however, information about dietary factors modulating this association is scarce. We investigated whether fat and carbohydrate intake modified the association of...
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| Veröffentlicht in: | The Journal of nutrition 2011-12, Vol.141 (12), p.2219-2225 |
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| creator | CORELLA, Dolores ARNETT, DonnaK ORDOVAS, Jose M TUCKER, KatherineL KABAGAMBE, Edmond K TSAI, Michael PARNELL, Laurence D LAI, Chao-Qiang LEE, Yu-Chi WARODOMWICHIT, Daruneewan HOPKINS, Paul N |
| description | Evidence that physical activity (PA) modulates the association between the fat mass and obesity-associated gene (FTO) and BMI is emerging; however, information about dietary factors modulating this association is scarce. We investigated whether fat and carbohydrate intake modified the association of FTO gene variation with BMI in two populations, including participants in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 1069) and in the Boston Puerto Rican Health (BPRHS) study (n = 1094). We assessed energy, nutrient intake, and PA using validated questionnaires. Genetic variability at the FTO locus was characterized by polymorphisms rs9939609 (in the GOLDN) and rs1121980 (in the GOLDN and BPRHS). We found significant interactions between PA and FTO on BMI in the GOLDN but not in the BPRHS. We found a significant interaction between SFA intake and FTO on BMI, which was stronger than that of total fat and was present in both populations (P-interaction = 0.007 in the GOLDN and P-interaction = 0.014 in BPRHS for categorical; and P-interaction = 0.028 in the GOLDN and P-interaction = 0.041 in BPRHS for continuous SFA). Thus, homozygous participants for the FTO-risk allele had a higher mean BMI than the other genotypes only when they had a high-SFA intake (above the population mean: 29.7 ± 0.7 vs. 28.1 ± 0.5 kg/m²; P = 0.037 in the GOLDN and 33.6. ± 0.8 vs. 31.2 ± 0.4 kg/m²; P = 0.006 in BPRHS). No associations with BMI were found at lower SFA intakes. We found no significant interactions with carbohydrate intake. In conclusion, SFA intake modulates the association between FTO and BMI in American populations. |
| doi_str_mv | 10.3945/jn.111.143826 |
| format | Article |
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We investigated whether fat and carbohydrate intake modified the association of FTO gene variation with BMI in two populations, including participants in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 1069) and in the Boston Puerto Rican Health (BPRHS) study (n = 1094). We assessed energy, nutrient intake, and PA using validated questionnaires. Genetic variability at the FTO locus was characterized by polymorphisms rs9939609 (in the GOLDN) and rs1121980 (in the GOLDN and BPRHS). We found significant interactions between PA and FTO on BMI in the GOLDN but not in the BPRHS. We found a significant interaction between SFA intake and FTO on BMI, which was stronger than that of total fat and was present in both populations (P-interaction = 0.007 in the GOLDN and P-interaction = 0.014 in BPRHS for categorical; and P-interaction = 0.028 in the GOLDN and P-interaction = 0.041 in BPRHS for continuous SFA). Thus, homozygous participants for the FTO-risk allele had a higher mean BMI than the other genotypes only when they had a high-SFA intake (above the population mean: 29.7 ± 0.7 vs. 28.1 ± 0.5 kg/m²; P = 0.037 in the GOLDN and 33.6. ± 0.8 vs. 31.2 ± 0.4 kg/m²; P = 0.006 in BPRHS). No associations with BMI were found at lower SFA intakes. We found no significant interactions with carbohydrate intake. In conclusion, SFA intake modulates the association between FTO and BMI in American populations.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.3945/jn.111.143826</identifier><identifier>PMID: 22049296</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: American Society for Nutrition</publisher><subject>administration & dosage ; Adult ; Aged ; Alleles ; Alpha-Ketoglutarate-Dependent Dioxygenase FTO ; Biological and medical sciences ; Body mass ; Body Mass Index ; carbohydrate intake ; Carbohydrates ; Diet ; Dietary Fats ; Dietary Fats - administration & dosage ; Drugs ; energy ; Energy Intake ; epidemiology ; Exercise ; fat intake ; Fatty Acids ; Fatty Acids - administration & dosage ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Genetic Predisposition to Disease ; Genetic Predisposition to Disease - epidemiology ; genetic variation ; Genetics ; genotype ; Health ; Humans ; Interviews as Topic ; Life Style ; Linear Models ; Lipids ; loci ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Multivariate Analysis ; Nutrition ; Nutritional Epidemiology ; Obesity ; Obesity - epidemiology ; Obesity - genetics ; physical activity ; Polymorphism, Single Nucleotide ; Proteins ; Proteins - genetics ; questionnaires ; saturated fatty acids ; Surveys and Questionnaires ; United States ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The Journal of nutrition, 2011-12, Vol.141 (12), p.2219-2225</ispartof><rights>2015 INIST-CNRS</rights><rights>2011 American Society for Nutrition 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c548t-8173fd72334fedd6859dcf8e73eedad4033d597a510a8bc94012e0df6d75ee393</citedby><cites>FETCH-LOGICAL-c548t-8173fd72334fedd6859dcf8e73eedad4033d597a510a8bc94012e0df6d75ee393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,778,782,883,27907,27908</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24790212$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22049296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CORELLA, Dolores</creatorcontrib><creatorcontrib>ARNETT, DonnaK</creatorcontrib><creatorcontrib>ORDOVAS, Jose M</creatorcontrib><creatorcontrib>TUCKER, KatherineL</creatorcontrib><creatorcontrib>KABAGAMBE, Edmond K</creatorcontrib><creatorcontrib>TSAI, Michael</creatorcontrib><creatorcontrib>PARNELL, Laurence D</creatorcontrib><creatorcontrib>LAI, Chao-Qiang</creatorcontrib><creatorcontrib>LEE, Yu-Chi</creatorcontrib><creatorcontrib>WARODOMWICHIT, Daruneewan</creatorcontrib><creatorcontrib>HOPKINS, Paul N</creatorcontrib><title>A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Evidence that physical activity (PA) modulates the association between the fat mass and obesity-associated gene (FTO) and BMI is emerging; however, information about dietary factors modulating this association is scarce. We investigated whether fat and carbohydrate intake modified the association of FTO gene variation with BMI in two populations, including participants in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 1069) and in the Boston Puerto Rican Health (BPRHS) study (n = 1094). We assessed energy, nutrient intake, and PA using validated questionnaires. Genetic variability at the FTO locus was characterized by polymorphisms rs9939609 (in the GOLDN) and rs1121980 (in the GOLDN and BPRHS). We found significant interactions between PA and FTO on BMI in the GOLDN but not in the BPRHS. We found a significant interaction between SFA intake and FTO on BMI, which was stronger than that of total fat and was present in both populations (P-interaction = 0.007 in the GOLDN and P-interaction = 0.014 in BPRHS for categorical; and P-interaction = 0.028 in the GOLDN and P-interaction = 0.041 in BPRHS for continuous SFA). Thus, homozygous participants for the FTO-risk allele had a higher mean BMI than the other genotypes only when they had a high-SFA intake (above the population mean: 29.7 ± 0.7 vs. 28.1 ± 0.5 kg/m²; P = 0.037 in the GOLDN and 33.6. ± 0.8 vs. 31.2 ± 0.4 kg/m²; P = 0.006 in BPRHS). No associations with BMI were found at lower SFA intakes. We found no significant interactions with carbohydrate intake. In conclusion, SFA intake modulates the association between FTO and BMI in American populations.</description><subject>administration & dosage</subject><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</subject><subject>Biological and medical sciences</subject><subject>Body mass</subject><subject>Body Mass Index</subject><subject>carbohydrate intake</subject><subject>Carbohydrates</subject><subject>Diet</subject><subject>Dietary Fats</subject><subject>Dietary Fats - administration & dosage</subject><subject>Drugs</subject><subject>energy</subject><subject>Energy Intake</subject><subject>epidemiology</subject><subject>Exercise</subject><subject>fat intake</subject><subject>Fatty Acids</subject><subject>Fatty Acids - administration & dosage</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetic Predisposition to Disease - epidemiology</subject><subject>genetic variation</subject><subject>Genetics</subject><subject>genotype</subject><subject>Health</subject><subject>Humans</subject><subject>Interviews as Topic</subject><subject>Life Style</subject><subject>Linear Models</subject><subject>Lipids</subject><subject>loci</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nutrition</subject><subject>Nutritional Epidemiology</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Obesity - genetics</subject><subject>physical activity</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Proteins</subject><subject>Proteins - genetics</subject><subject>questionnaires</subject><subject>saturated fatty acids</subject><subject>Surveys and Questionnaires</subject><subject>United States</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0r1vEzEYB2ALgWgojKzIC4Llgr_OZy9IaUXbSK06FGbLsd9LHC6-YjugiH8et0kLLLDYkt_HP_njReg1JVOuRfthHaeU0ikVXDH5BE1oK2gjKSFP0YQQxhpOpTxCL3JeE0Ko0Oo5OmKMCM20nKCfM3wRlis8j8V-BTz2-MaWbbIFPD6zpezwzAWf8U1JEJdlBTHjOuJZzqMLtoQx4gWUHwDxfr3uwVc2Z2yjx9cLyKHsmgdcM88hwn3t5Gr-Ej3r7ZDh1WE-Rl_OPn0-vWgur8_np7PLxrVClUbRjve-Y5yLHryXqtXe9Qo6DuCtF4Rz3-rOtpRYtXBaEMqA-F76rgXgmh-jj_vc2-1iA95BLMkO5jaFjU07M9pg_q7EsDLL8bvhjHHV3QW8OwSk8dsWcjGbkB0Mg40wbrPRpJX19VVX5ft_yvpNVAqiBfs_JVwoyjlvK2321KUx5wT949kpMXddYNbR1C4w-y6o_s2fF37UD99ewdsDsNnZoU82upB_O9FpwijjvwBmH7p4</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>CORELLA, Dolores</creator><creator>ARNETT, DonnaK</creator><creator>ORDOVAS, Jose M</creator><creator>TUCKER, KatherineL</creator><creator>KABAGAMBE, Edmond K</creator><creator>TSAI, Michael</creator><creator>PARNELL, Laurence D</creator><creator>LAI, Chao-Qiang</creator><creator>LEE, Yu-Chi</creator><creator>WARODOMWICHIT, Daruneewan</creator><creator>HOPKINS, Paul N</creator><general>American Society for Nutrition</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7S9</scope><scope>L.6</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111201</creationdate><title>A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI</title><author>CORELLA, Dolores ; ARNETT, DonnaK ; ORDOVAS, Jose M ; TUCKER, KatherineL ; KABAGAMBE, Edmond K ; TSAI, Michael ; PARNELL, Laurence D ; LAI, Chao-Qiang ; LEE, Yu-Chi ; WARODOMWICHIT, Daruneewan ; HOPKINS, Paul N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c548t-8173fd72334fedd6859dcf8e73eedad4033d597a510a8bc94012e0df6d75ee393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>administration & dosage</topic><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Alpha-Ketoglutarate-Dependent Dioxygenase FTO</topic><topic>Biological and medical sciences</topic><topic>Body mass</topic><topic>Body Mass Index</topic><topic>carbohydrate intake</topic><topic>Carbohydrates</topic><topic>Diet</topic><topic>Dietary Fats</topic><topic>Dietary Fats - administration & dosage</topic><topic>Drugs</topic><topic>energy</topic><topic>Energy Intake</topic><topic>epidemiology</topic><topic>Exercise</topic><topic>fat intake</topic><topic>Fatty Acids</topic><topic>Fatty Acids - administration & dosage</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetic Predisposition to Disease - epidemiology</topic><topic>genetic variation</topic><topic>Genetics</topic><topic>genotype</topic><topic>Health</topic><topic>Humans</topic><topic>Interviews as Topic</topic><topic>Life Style</topic><topic>Linear Models</topic><topic>Lipids</topic><topic>loci</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nutrition</topic><topic>Nutritional Epidemiology</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Obesity - genetics</topic><topic>physical activity</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Proteins</topic><topic>Proteins - genetics</topic><topic>questionnaires</topic><topic>saturated fatty acids</topic><topic>Surveys and Questionnaires</topic><topic>United States</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CORELLA, Dolores</creatorcontrib><creatorcontrib>ARNETT, DonnaK</creatorcontrib><creatorcontrib>ORDOVAS, Jose M</creatorcontrib><creatorcontrib>TUCKER, KatherineL</creatorcontrib><creatorcontrib>KABAGAMBE, Edmond K</creatorcontrib><creatorcontrib>TSAI, Michael</creatorcontrib><creatorcontrib>PARNELL, Laurence D</creatorcontrib><creatorcontrib>LAI, Chao-Qiang</creatorcontrib><creatorcontrib>LEE, Yu-Chi</creatorcontrib><creatorcontrib>WARODOMWICHIT, Daruneewan</creatorcontrib><creatorcontrib>HOPKINS, Paul N</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CORELLA, Dolores</au><au>ARNETT, DonnaK</au><au>ORDOVAS, Jose M</au><au>TUCKER, KatherineL</au><au>KABAGAMBE, Edmond K</au><au>TSAI, Michael</au><au>PARNELL, Laurence D</au><au>LAI, Chao-Qiang</au><au>LEE, Yu-Chi</au><au>WARODOMWICHIT, Daruneewan</au><au>HOPKINS, Paul N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>141</volume><issue>12</issue><spage>2219</spage><epage>2225</epage><pages>2219-2225</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>Evidence that physical activity (PA) modulates the association between the fat mass and obesity-associated gene (FTO) and BMI is emerging; however, information about dietary factors modulating this association is scarce. We investigated whether fat and carbohydrate intake modified the association of FTO gene variation with BMI in two populations, including participants in the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) study (n = 1069) and in the Boston Puerto Rican Health (BPRHS) study (n = 1094). We assessed energy, nutrient intake, and PA using validated questionnaires. Genetic variability at the FTO locus was characterized by polymorphisms rs9939609 (in the GOLDN) and rs1121980 (in the GOLDN and BPRHS). We found significant interactions between PA and FTO on BMI in the GOLDN but not in the BPRHS. We found a significant interaction between SFA intake and FTO on BMI, which was stronger than that of total fat and was present in both populations (P-interaction = 0.007 in the GOLDN and P-interaction = 0.014 in BPRHS for categorical; and P-interaction = 0.028 in the GOLDN and P-interaction = 0.041 in BPRHS for continuous SFA). Thus, homozygous participants for the FTO-risk allele had a higher mean BMI than the other genotypes only when they had a high-SFA intake (above the population mean: 29.7 ± 0.7 vs. 28.1 ± 0.5 kg/m²; P = 0.037 in the GOLDN and 33.6. ± 0.8 vs. 31.2 ± 0.4 kg/m²; P = 0.006 in BPRHS). No associations with BMI were found at lower SFA intakes. We found no significant interactions with carbohydrate intake. In conclusion, SFA intake modulates the association between FTO and BMI in American populations.</abstract><cop>Bethesda, MD</cop><pub>American Society for Nutrition</pub><pmid>22049296</pmid><doi>10.3945/jn.111.143826</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | administration & dosage Adult Aged Alleles Alpha-Ketoglutarate-Dependent Dioxygenase FTO Biological and medical sciences Body mass Body Mass Index carbohydrate intake Carbohydrates Diet Dietary Fats Dietary Fats - administration & dosage Drugs energy Energy Intake epidemiology Exercise fat intake Fatty Acids Fatty Acids - administration & dosage Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Genetic Predisposition to Disease Genetic Predisposition to Disease - epidemiology genetic variation Genetics genotype Health Humans Interviews as Topic Life Style Linear Models Lipids loci Male Medical sciences Metabolic diseases Middle Aged Multivariate Analysis Nutrition Nutritional Epidemiology Obesity Obesity - epidemiology Obesity - genetics physical activity Polymorphism, Single Nucleotide Proteins Proteins - genetics questionnaires saturated fatty acids Surveys and Questionnaires United States Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | A High Intake of Saturated Fatty Acids Strengthens the Association between the Fat Mass and Obesity-Associated Gene and BMI |
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