The LRF transcription factor regulates mature B cell development and the germinal center response in mice

B cells play a central role in immune system function. Deregulation of normal B cell maturation can lead to the development of autoimmune syndromes as well as B cell malignancies. Elucidation of the molecular features of normal B cell development is important for the development of new target therap...

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Veröffentlicht in:	The Journal of clinical investigation 2011-07, Vol.121 (7), p.2583-2598
Hauptverfasser:	Sakurai, Nagisa, Maeda, Manami, Lee, Sung-Uk, Ishikawa, Yuichi, Li, Min, Williams, John C, Wang, Lisheng, Su, Leila, Suzuki, Mai, Saito, Toshiki I, Chiba, Shigeru, Casola, Stefano, Yagita, Hideo, Teruya-Feldstein, Julie, Tsuzuki, Shinobu, Bhatia, Ravi, Maeda, Takahiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Animals Antigens Autoimmune diseases B cells B-Lymphocytes - immunology B-Lymphocytes - physiology Biomedical research Cell Differentiation - immunology Cells Cyclin-Dependent Kinase Inhibitor p16 - genetics Cyclin-Dependent Kinase Inhibitor p16 - immunology DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology Gene Expression Regulation Genes Genetic aspects Germinal Center - cytology Germinal Center - immunology Germinal Center - physiology Immune response Leukemia Lymphocytes Lymphoma Mice Mice, Knockout Microarray Analysis Models, Molecular Mutation Physiological aspects Protein Conformation Protein Multimerization Proteins Risk factors RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Spleen - cytology Transcription factors Transcription Factors - chemistry Transcription Factors - genetics Transcription Factors - immunology
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