Density of human bone marrow stromal cells regulates commitment to vascular lineages

Mechanisms underlying the vascular differentiation of human bone marrow stromal cells (HBMSCs) and their contribution to neovascularisation are poorly understood. We report the essential role of cell density-induced signals in directing HBMSCs along endothelial or smooth muscle lineages. Plating HBM...

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Veröffentlicht in:	Stem cell research 2011-05, Vol.6 (3), p.238-250
Hauptverfasser:	Whyte, Jemima L., Ball, Stephen G., Shuttleworth, C. Adrian, Brennan, Keith, Kielty, Cay M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Bone Marrow Cells - cytology Bone Marrow Cells - metabolism Cell Count Cell Differentiation Cell Lineage Cells, Cultured Endothelial Cells - cytology Endothelial Cells - metabolism Female Humans Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - metabolism Regular Stromal Cells - cytology Stromal Cells - metabolism Vascular Endothelial Growth Factor A - metabolism Young Adult
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