Links between Electrophysiological and Molecular Pathology of Amyotrophic Lateral Sclerosis

Multiple deficits have been described in amyotrophic lateral sclerosis (ALS), from the first changes in normal functioning of the motoneurons and glia to the eventual loss of spinal and cortical motoneurons. In this review, current results, including changes in size, and electrical properties of mot...

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Veröffentlicht in:	Integrative and comparative biology 2011-12, Vol.51 (6), p.913-925
1. Verfasser:	Quinlan, Katharina A
Format:	Artikel
Sprache:	eng
Schlagworte:	Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - enzymology Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - physiopathology Animal models Animals Astrocytes - metabolism Astrocytes - physiology Axons Calcium Calcium - metabolism Calcium buffering Calcium-Binding Proteins - metabolism Cortex Disease Models, Animal Electrical properties Electrophysiological Phenomena electrophysiology Endoplasmic reticulum Endoplasmic Reticulum - physiology Excitotoxicity Glia Glutamic acid Glutamic Acid - metabolism I've Got Rhythm: Neuronal Mechanisms of Central Pattern Generators Membrane Potential, Mitochondrial Mice Mitochondria Molecular modelling Motor neurons Motor Neurons - physiology mutants Mutation Nervous system diseases Neural Conduction Neurons Neuroscience Pathology Proteolysis Rodents Spinal cord Stress Stress, Physiological Superoxide dismutase Superoxide Dismutase - genetics Superoxide Dismutase - metabolism Superoxide Dismutase-1 Transgenic animals
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