A Campylobacter jejuni Dps homolog has a role in intracellular survival and in the development of campylobacterosis in neonate piglets

Iron acquisition is an absolute requirement by most microorganisms for host survival. In this work, we investigated the Campylobacter jejuni iron binding Dps protein for a potential role in virulence. In vitro assays using J774A.1 macrophage-like cells demonstrated a 2.5 log reduction in C. jejuni s...

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Veröffentlicht in:	Foodborne pathogens and disease 2011-12, Vol.8 (12), p.1263-1268
Hauptverfasser:	Theoret, James R, Cooper, Kerry K, Glock, Robert D, Joens, Lynn A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacterial Shedding Campylobacter Infections - microbiology Campylobacter Infections - veterinary Campylobacter jejuni - genetics Campylobacter jejuni - growth & development Campylobacter jejuni - pathogenicity Cell Line Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Epithelial Cells - microbiology Feces - microbiology Gene Expression Regulation, Bacterial - genetics Genetic Complementation Test Iron-Binding Proteins - genetics Iron-Binding Proteins - metabolism Macrophages - microbiology Microbial Viability Mutation Original Swine Swine Diseases - microbiology Time Factors Transcriptional Activation Up-Regulation - genetics Virulence Factors - genetics Virulence Factors - metabolism
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