Mother’s lifetime nutrition and the size, shape and efficiency of the placenta
Abstract Background Studies have shown that the shape and size of the placenta at birth predict blood pressure in later life. The influences that determine placental morphology are largely unknown. We have examined the role of mother’s body size. Methods We studied 522 neonates who were born in a ma...
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| Veröffentlicht in: | Placenta (Eastbourne) 2011-11, Vol.32 (11), p.806-810 |
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| creator | Winder, N.R Krishnaveni, G.V Veena, S.R Hill, J.C Karat, C.L.S Thornburg, K.L Fall, C.H.D Barker, D.J.P |
| description | Abstract Background Studies have shown that the shape and size of the placenta at birth predict blood pressure in later life. The influences that determine placental morphology are largely unknown. We have examined the role of mother’s body size. Methods We studied 522 neonates who were born in a maternity hospital in Mysore, South India. The weight of the placenta and the length and breadth of its surface, were measured after delivery. Results Higher maternal fat mass predicted a larger placental surface ( p = 0.02), while larger maternal head circumference predicted a more oval placental surface ( p = 0.03). Higher maternal fat mass and larger maternal head circumference were associated with greater placental efficiency, indicated by lower ratios of the length ( p = 0.0003 and p = 0.0001 respectively) and breadth ( p = 0.0002 and p |
| doi_str_mv | 10.1016/j.placenta.2011.09.001 |
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The influences that determine placental morphology are largely unknown. We have examined the role of mother’s body size. Methods We studied 522 neonates who were born in a maternity hospital in Mysore, South India. The weight of the placenta and the length and breadth of its surface, were measured after delivery. Results Higher maternal fat mass predicted a larger placental surface ( p = 0.02), while larger maternal head circumference predicted a more oval placental surface ( p = 0.03). Higher maternal fat mass and larger maternal head circumference were associated with greater placental efficiency, indicated by lower ratios of the length ( p = 0.0003 and p = 0.0001 respectively) and breadth ( p = 0.0002 and p < 0.0001) of the surface to birthweight. In a sub-sample of 51 mothers whose own birthweight was available, higher maternal birthweight was related to lower ratios of the length and breadth of the surface to birthweight ( p = 0.01 and 0.002). Maternal height was unrelated to placental size or shape. Conclusions Higher maternal fat mass, reflecting the mother’s current nutritional state, and larger maternal head circumference, reflecting the mother’s fetal/infant growth, are associated with changes in the shape and size of the placental surface and greater placental efficiency. We suggest that these associations reflect effects of the mother’s nutrition at different stages of her lifecourse on the development of the placenta and on materno-placento-fetal transfer of nutrients.</description><identifier>ISSN: 0143-4004</identifier><identifier>EISSN: 1532-3102</identifier><identifier>DOI: 10.1016/j.placenta.2011.09.001</identifier><identifier>PMID: 21924491</identifier><identifier>CODEN: PLACDF</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Adult ; Biological and medical sciences ; Birth Weight - physiology ; Birthweight ; Efficiency ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; India - epidemiology ; Infant, Newborn ; Internal Medicine ; Male ; Maternal body composition ; Maternal Nutritional Physiological Phenomena - physiology ; Mothers ; Nutrition Disorders - complications ; Nutrition Disorders - epidemiology ; Nutrition Disorders - physiopathology ; Nutritional Status - physiology ; Obstetrics and Gynecology ; Organ Size ; Placenta ; Placenta - anatomy & histology ; Placenta - physiology ; Placental efficiency ; Placentation ; Pregnancy ; Pregnancy Complications - epidemiology ; Pregnancy Complications - etiology ; Pregnancy Complications - physiopathology ; Prenatal Exposure Delayed Effects - epidemiology ; Prenatal Exposure Delayed Effects - physiopathology ; Young Adult</subject><ispartof>Placenta (Eastbourne), 2011-11, Vol.32 (11), p.806-810</ispartof><rights>Elsevier Ltd</rights><rights>2011 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c621t-b50a4f26e6242184e39134cf5052f81a37e8f0d1ddbca7dcd696bdd18dcbd1553</citedby><cites>FETCH-LOGICAL-c621t-b50a4f26e6242184e39134cf5052f81a37e8f0d1ddbca7dcd696bdd18dcbd1553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0143400411004462$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24757774$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21924491$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winder, N.R</creatorcontrib><creatorcontrib>Krishnaveni, G.V</creatorcontrib><creatorcontrib>Veena, S.R</creatorcontrib><creatorcontrib>Hill, J.C</creatorcontrib><creatorcontrib>Karat, C.L.S</creatorcontrib><creatorcontrib>Thornburg, K.L</creatorcontrib><creatorcontrib>Fall, C.H.D</creatorcontrib><creatorcontrib>Barker, D.J.P</creatorcontrib><title>Mother’s lifetime nutrition and the size, shape and efficiency of the placenta</title><title>Placenta (Eastbourne)</title><addtitle>Placenta</addtitle><description>Abstract Background Studies have shown that the shape and size of the placenta at birth predict blood pressure in later life. The influences that determine placental morphology are largely unknown. We have examined the role of mother’s body size. Methods We studied 522 neonates who were born in a maternity hospital in Mysore, South India. The weight of the placenta and the length and breadth of its surface, were measured after delivery. Results Higher maternal fat mass predicted a larger placental surface ( p = 0.02), while larger maternal head circumference predicted a more oval placental surface ( p = 0.03). Higher maternal fat mass and larger maternal head circumference were associated with greater placental efficiency, indicated by lower ratios of the length ( p = 0.0003 and p = 0.0001 respectively) and breadth ( p = 0.0002 and p < 0.0001) of the surface to birthweight. In a sub-sample of 51 mothers whose own birthweight was available, higher maternal birthweight was related to lower ratios of the length and breadth of the surface to birthweight ( p = 0.01 and 0.002). Maternal height was unrelated to placental size or shape. Conclusions Higher maternal fat mass, reflecting the mother’s current nutritional state, and larger maternal head circumference, reflecting the mother’s fetal/infant growth, are associated with changes in the shape and size of the placental surface and greater placental efficiency. We suggest that these associations reflect effects of the mother’s nutrition at different stages of her lifecourse on the development of the placenta and on materno-placento-fetal transfer of nutrients.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Birth Weight - physiology</subject><subject>Birthweight</subject><subject>Efficiency</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>India - epidemiology</subject><subject>Infant, Newborn</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Maternal body composition</subject><subject>Maternal Nutritional Physiological Phenomena - physiology</subject><subject>Mothers</subject><subject>Nutrition Disorders - complications</subject><subject>Nutrition Disorders - epidemiology</subject><subject>Nutrition Disorders - physiopathology</subject><subject>Nutritional Status - physiology</subject><subject>Obstetrics and Gynecology</subject><subject>Organ Size</subject><subject>Placenta</subject><subject>Placenta - anatomy & histology</subject><subject>Placenta - physiology</subject><subject>Placental efficiency</subject><subject>Placentation</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Pregnancy Complications - etiology</subject><subject>Pregnancy Complications - physiopathology</subject><subject>Prenatal Exposure Delayed Effects - epidemiology</subject><subject>Prenatal Exposure Delayed Effects - physiopathology</subject><subject>Young Adult</subject><issn>0143-4004</issn><issn>1532-3102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUsuO1DAQtBCInV34hVUuiAsJbttJJpcVqxULSItAAs6WY7cZDxl7sDMrDSd-g9_jS3DmsTwuXGzJXV1V7mpCzoFWQKF5vqzWg9LoR1UxClDRrqIU7pEZ1JyVHCi7T2YUBC8FpeKEnKa0pJR2AthDcsKgY0J0MCPv34ZxgfHn9x-pGJzF0a2w8JsxutEFXyhvilwvkvuGz4q0UGvcvaG1Tjv0elsEu0Mc7TwiD6waEj4-3Gfk0_XLj1evy5t3r95cXd6UumEwln1NlbCswYYJBnOBvAMutK1pzewcFG9xbqkBY3qtWqNN0zW9MTA3ujdQ1_yMXOx515t-hWbSjmqQ6-hWKm5lUE7-XfFuIT-HW8kZ47wTmeDpgSCGrxtMo1y5pHEYlMewSbKjrGl5tpORzR6pY0gpor1TASqnNORSHr8vpzQk7WROIzee_-nxru04_gx4cgCopNVgo_Lapd840dZt205eX-xxmCd66zDKtJs-GhdRj9IE938vF_9Q6MF5l1W_4BbTMmyiz3lJkIlJKj9MuzOtDkA-RMP4L8Rewtk</recordid><startdate>20111101</startdate><enddate>20111101</enddate><creator>Winder, N.R</creator><creator>Krishnaveni, G.V</creator><creator>Veena, S.R</creator><creator>Hill, J.C</creator><creator>Karat, C.L.S</creator><creator>Thornburg, K.L</creator><creator>Fall, C.H.D</creator><creator>Barker, D.J.P</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20111101</creationdate><title>Mother’s lifetime nutrition and the size, shape and efficiency of the placenta</title><author>Winder, N.R ; Krishnaveni, G.V ; Veena, S.R ; Hill, J.C ; Karat, C.L.S ; Thornburg, K.L ; Fall, C.H.D ; Barker, D.J.P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c621t-b50a4f26e6242184e39134cf5052f81a37e8f0d1ddbca7dcd696bdd18dcbd1553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Birth Weight - physiology</topic><topic>Birthweight</topic><topic>Efficiency</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>India - epidemiology</topic><topic>Infant, Newborn</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Maternal body composition</topic><topic>Maternal Nutritional Physiological Phenomena - physiology</topic><topic>Mothers</topic><topic>Nutrition Disorders - complications</topic><topic>Nutrition Disorders - epidemiology</topic><topic>Nutrition Disorders - physiopathology</topic><topic>Nutritional Status - physiology</topic><topic>Obstetrics and Gynecology</topic><topic>Organ Size</topic><topic>Placenta</topic><topic>Placenta - anatomy & histology</topic><topic>Placenta - physiology</topic><topic>Placental efficiency</topic><topic>Placentation</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Pregnancy Complications - etiology</topic><topic>Pregnancy Complications - physiopathology</topic><topic>Prenatal Exposure Delayed Effects - epidemiology</topic><topic>Prenatal Exposure Delayed Effects - physiopathology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winder, N.R</creatorcontrib><creatorcontrib>Krishnaveni, G.V</creatorcontrib><creatorcontrib>Veena, S.R</creatorcontrib><creatorcontrib>Hill, J.C</creatorcontrib><creatorcontrib>Karat, C.L.S</creatorcontrib><creatorcontrib>Thornburg, K.L</creatorcontrib><creatorcontrib>Fall, C.H.D</creatorcontrib><creatorcontrib>Barker, D.J.P</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Placenta (Eastbourne)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winder, N.R</au><au>Krishnaveni, G.V</au><au>Veena, S.R</au><au>Hill, J.C</au><au>Karat, C.L.S</au><au>Thornburg, K.L</au><au>Fall, C.H.D</au><au>Barker, D.J.P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mother’s lifetime nutrition and the size, shape and efficiency of the placenta</atitle><jtitle>Placenta (Eastbourne)</jtitle><addtitle>Placenta</addtitle><date>2011-11-01</date><risdate>2011</risdate><volume>32</volume><issue>11</issue><spage>806</spage><epage>810</epage><pages>806-810</pages><issn>0143-4004</issn><eissn>1532-3102</eissn><coden>PLACDF</coden><abstract>Abstract Background Studies have shown that the shape and size of the placenta at birth predict blood pressure in later life. The influences that determine placental morphology are largely unknown. We have examined the role of mother’s body size. Methods We studied 522 neonates who were born in a maternity hospital in Mysore, South India. The weight of the placenta and the length and breadth of its surface, were measured after delivery. Results Higher maternal fat mass predicted a larger placental surface ( p = 0.02), while larger maternal head circumference predicted a more oval placental surface ( p = 0.03). Higher maternal fat mass and larger maternal head circumference were associated with greater placental efficiency, indicated by lower ratios of the length ( p = 0.0003 and p = 0.0001 respectively) and breadth ( p = 0.0002 and p < 0.0001) of the surface to birthweight. In a sub-sample of 51 mothers whose own birthweight was available, higher maternal birthweight was related to lower ratios of the length and breadth of the surface to birthweight ( p = 0.01 and 0.002). Maternal height was unrelated to placental size or shape. Conclusions Higher maternal fat mass, reflecting the mother’s current nutritional state, and larger maternal head circumference, reflecting the mother’s fetal/infant growth, are associated with changes in the shape and size of the placental surface and greater placental efficiency. We suggest that these associations reflect effects of the mother’s nutrition at different stages of her lifecourse on the development of the placenta and on materno-placento-fetal transfer of nutrients.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>21924491</pmid><doi>10.1016/j.placenta.2011.09.001</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Biological and medical sciences Birth Weight - physiology Birthweight Efficiency Embryology: invertebrates and vertebrates. Teratology Female Fundamental and applied biological sciences. Psychology Humans India - epidemiology Infant, Newborn Internal Medicine Male Maternal body composition Maternal Nutritional Physiological Phenomena - physiology Mothers Nutrition Disorders - complications Nutrition Disorders - epidemiology Nutrition Disorders - physiopathology Nutritional Status - physiology Obstetrics and Gynecology Organ Size Placenta Placenta - anatomy & histology Placenta - physiology Placental efficiency Placentation Pregnancy Pregnancy Complications - epidemiology Pregnancy Complications - etiology Pregnancy Complications - physiopathology Prenatal Exposure Delayed Effects - epidemiology Prenatal Exposure Delayed Effects - physiopathology Young Adult |
| title | Mother’s lifetime nutrition and the size, shape and efficiency of the placenta |
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