Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes
Conventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable met...
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| Veröffentlicht in: | Nature materials 2011-10, Vol.10 (12), p.980-986 |
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| creator | Song, Yong-Ak Melik, Rohat Rabie, Amr N. Ibrahim, Ahmed M. S. Moses, David Tan, Ara Han, Jongyoon Lin, Samuel J. |
| description | Conventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable method that suppresses unwanted nerve signals. We have developed an electrochemical method to activate and inhibit a nerve by electrically modulating ion concentrations
in situ
along the nerve. Using ion-selective membranes to achieve different excitability states of the nerve, we observe either a reduction of the electrical threshold for stimulation by up to approximately 40%, or voluntary, reversible inhibition of nerve signal propagation. This low-threshold electrochemical stimulation method is applicable in current implantable neuroprosthetic devices, whereas the on-demand nerve-blocking mechanism could offer effective clinical intervention in disease states caused by uncontrolled nerve activation, such as epilepsy and chronic pain syndromes.
An electrochemical method that uses ion-selective membranes to electrically modulate ion concentrations
in situ
along a sciatic nerve
in vitro
allows for on-demand reversible inhibition of signal propagation as well as up to 40% reduction of the electrical threshold for stimulation. The method may be applicable in implantable neuroprosthetic devices. |
| doi_str_mv | 10.1038/nmat3146 |
| format | Article |
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in situ
along the nerve. Using ion-selective membranes to achieve different excitability states of the nerve, we observe either a reduction of the electrical threshold for stimulation by up to approximately 40%, or voluntary, reversible inhibition of nerve signal propagation. This low-threshold electrochemical stimulation method is applicable in current implantable neuroprosthetic devices, whereas the on-demand nerve-blocking mechanism could offer effective clinical intervention in disease states caused by uncontrolled nerve activation, such as epilepsy and chronic pain syndromes.
An electrochemical method that uses ion-selective membranes to electrically modulate ion concentrations
in situ
along a sciatic nerve
in vitro
allows for on-demand reversible inhibition of signal propagation as well as up to 40% reduction of the electrical threshold for stimulation. The method may be applicable in implantable neuroprosthetic devices.</description><identifier>ISSN: 1476-1122</identifier><identifier>EISSN: 1476-4660</identifier><identifier>DOI: 10.1038/nmat3146</identifier><identifier>PMID: 22019944</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>639/301/54/990 ; 692/699/375 ; Activation ; Animals ; Biomaterials ; Biomedical materials ; Chemistry and Materials Science ; Condensed Matter Physics ; Devices ; Disabilities ; Electric Stimulation ; Electric Stimulation Therapy - instrumentation ; Electric Stimulation Therapy - methods ; Electrochemical activation ; Electrochemistry ; Inhibition ; Ion concentration ; Ion-Selective Electrodes ; Ions - chemistry ; Materials Science ; Membranes ; Membranes, Artificial ; Muscle, Skeletal - innervation ; Nanotechnology ; Nerves ; Neurological disorders ; Optical and Electronic Materials ; Propagation ; Rana catesbeiana ; Sciatic Nerve - physiology ; Spinal cord injuries ; Stimulation</subject><ispartof>Nature materials, 2011-10, Vol.10 (12), p.980-986</ispartof><rights>Springer Nature Limited 2011</rights><rights>Copyright Nature Publishing Group Dec 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-604193c41dec117a2f81b2c1e72f5d16f98afcf59be73ebac88178b947f492b83</citedby><cites>FETCH-LOGICAL-c465t-604193c41dec117a2f81b2c1e72f5d16f98afcf59be73ebac88178b947f492b83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/nmat3146$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/nmat3146$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22019944$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Song, Yong-Ak</creatorcontrib><creatorcontrib>Melik, Rohat</creatorcontrib><creatorcontrib>Rabie, Amr N.</creatorcontrib><creatorcontrib>Ibrahim, Ahmed M. S.</creatorcontrib><creatorcontrib>Moses, David</creatorcontrib><creatorcontrib>Tan, Ara</creatorcontrib><creatorcontrib>Han, Jongyoon</creatorcontrib><creatorcontrib>Lin, Samuel J.</creatorcontrib><title>Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes</title><title>Nature materials</title><addtitle>Nature Mater</addtitle><addtitle>Nat Mater</addtitle><description>Conventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable method that suppresses unwanted nerve signals. We have developed an electrochemical method to activate and inhibit a nerve by electrically modulating ion concentrations
in situ
along the nerve. Using ion-selective membranes to achieve different excitability states of the nerve, we observe either a reduction of the electrical threshold for stimulation by up to approximately 40%, or voluntary, reversible inhibition of nerve signal propagation. This low-threshold electrochemical stimulation method is applicable in current implantable neuroprosthetic devices, whereas the on-demand nerve-blocking mechanism could offer effective clinical intervention in disease states caused by uncontrolled nerve activation, such as epilepsy and chronic pain syndromes.
An electrochemical method that uses ion-selective membranes to electrically modulate ion concentrations
in situ
along a sciatic nerve
in vitro
allows for on-demand reversible inhibition of signal propagation as well as up to 40% reduction of the electrical threshold for stimulation. The method may be applicable in implantable neuroprosthetic devices.</description><subject>639/301/54/990</subject><subject>692/699/375</subject><subject>Activation</subject><subject>Animals</subject><subject>Biomaterials</subject><subject>Biomedical materials</subject><subject>Chemistry and Materials Science</subject><subject>Condensed Matter Physics</subject><subject>Devices</subject><subject>Disabilities</subject><subject>Electric Stimulation</subject><subject>Electric Stimulation Therapy - instrumentation</subject><subject>Electric Stimulation Therapy - methods</subject><subject>Electrochemical activation</subject><subject>Electrochemistry</subject><subject>Inhibition</subject><subject>Ion concentration</subject><subject>Ion-Selective Electrodes</subject><subject>Ions - chemistry</subject><subject>Materials Science</subject><subject>Membranes</subject><subject>Membranes, Artificial</subject><subject>Muscle, Skeletal - innervation</subject><subject>Nanotechnology</subject><subject>Nerves</subject><subject>Neurological disorders</subject><subject>Optical and Electronic Materials</subject><subject>Propagation</subject><subject>Rana catesbeiana</subject><subject>Sciatic Nerve - physiology</subject><subject>Spinal cord injuries</subject><subject>Stimulation</subject><issn>1476-1122</issn><issn>1476-4660</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9ks1u1DAQxy0EomVB4glQxAU4pNiO7cSXSqgqFKlSL3C2HGeycRXbxXYW9Q14bLzd3baAxGnsmZ_-84nQa4JPCG66j97p3BAmnqBjwlpRMyHw0_2bEEqP0IuUrjGmhHPxHB1RiomUjB2jX-czmByDmcBZo-dKm2w3OtvgK-2HyvrJ9vbuG8bKwxKDW5JZZh2rdJsyuFTlKYZlPVUuDMV_YLfGBG_A53jnTNVPm6etv06wzWo3UDlwfdQe0kv0bNRzgld7u0LfP59_O7uoL6--fD37dFkbJniuBWZENoaRAQwhraZjR3pqCLR05AMRo-z0aEYue2gb6LXpOtJ2vWTtyCTtu2aFTne6N0vvYNiVN6ubaJ2Otypoq_6MeDupddiohtKGdrwIvNsLxPBjgZSVs8nAPJcuwpKUxFwK1klWyPf_JUlZguCclRWu0Nu_0OuwRF8GoSTFlDHR4gc9E0NKEcb7qglW2ztQhzso6JvHXd6Dh8UX4MMOSCXk1xAfEv4j9ht4LMDu</recordid><startdate>20111023</startdate><enddate>20111023</enddate><creator>Song, Yong-Ak</creator><creator>Melik, Rohat</creator><creator>Rabie, Amr N.</creator><creator>Ibrahim, Ahmed M. 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S.</au><au>Moses, David</au><au>Tan, Ara</au><au>Han, Jongyoon</au><au>Lin, Samuel J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes</atitle><jtitle>Nature materials</jtitle><stitle>Nature Mater</stitle><addtitle>Nat Mater</addtitle><date>2011-10-23</date><risdate>2011</risdate><volume>10</volume><issue>12</issue><spage>980</spage><epage>986</epage><pages>980-986</pages><issn>1476-1122</issn><eissn>1476-4660</eissn><abstract>Conventional functional electrical stimulation aims to restore functional motor activity of patients with disabilities resulting from spinal cord injury or neurological disorders. However, intervention with functional electrical stimulation in neurological diseases lacks an effective implantable method that suppresses unwanted nerve signals. We have developed an electrochemical method to activate and inhibit a nerve by electrically modulating ion concentrations
in situ
along the nerve. Using ion-selective membranes to achieve different excitability states of the nerve, we observe either a reduction of the electrical threshold for stimulation by up to approximately 40%, or voluntary, reversible inhibition of nerve signal propagation. This low-threshold electrochemical stimulation method is applicable in current implantable neuroprosthetic devices, whereas the on-demand nerve-blocking mechanism could offer effective clinical intervention in disease states caused by uncontrolled nerve activation, such as epilepsy and chronic pain syndromes.
An electrochemical method that uses ion-selective membranes to electrically modulate ion concentrations
in situ
along a sciatic nerve
in vitro
allows for on-demand reversible inhibition of signal propagation as well as up to 40% reduction of the electrical threshold for stimulation. The method may be applicable in implantable neuroprosthetic devices.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>22019944</pmid><doi>10.1038/nmat3146</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 639/301/54/990 692/699/375 Activation Animals Biomaterials Biomedical materials Chemistry and Materials Science Condensed Matter Physics Devices Disabilities Electric Stimulation Electric Stimulation Therapy - instrumentation Electric Stimulation Therapy - methods Electrochemical activation Electrochemistry Inhibition Ion concentration Ion-Selective Electrodes Ions - chemistry Materials Science Membranes Membranes, Artificial Muscle, Skeletal - innervation Nanotechnology Nerves Neurological disorders Optical and Electronic Materials Propagation Rana catesbeiana Sciatic Nerve - physiology Spinal cord injuries Stimulation |
| title | Electrochemical activation and inhibition of neuromuscular systems through modulation of ion concentrations with ion-selective membranes |
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