The H/ACA RNP assembly factor SHQ1 functions as an RNA mimic

SHQ1 is an essential assembly factor for H/ACA ribonucleoproteins (RNPs) required for ribosome biogenesis, pre-mRNA splicing, and telomere maintenance. SHQ1 binds dyskerin/NAP57, the catalytic subunit of human H/ACA RNPs, and this interaction is modulated by mutations causing X-linked dyskeratosis c...

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Veröffentlicht in:	Genes & development 2011-11, Vol.25 (22), p.2398-2408
Hauptverfasser:	Walbott, Hélène, Machado-Pinilla, Rosario, Liger, Dominique, Blaud, Magali, Réty, Stéphane, Grozdanov, Petar N, Godin, Kate, van Tilbeurgh, Herman, Varani, Gabriele, Meier, U Thomas, Leulliot, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biochemistry, Molecular Biology Biophysics Cell Survival Humans Hydro-Lyases - chemistry Hydro-Lyases - metabolism Life Sciences Microtubule-Associated Proteins - chemistry Microtubule-Associated Proteins - metabolism Models, Molecular Molecular biology Molecular Mimicry Mutation Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Binding Protein Folding Protein Structure, Tertiary Recombinant Proteins - metabolism Research Paper Ribonucleoproteins, Small Nuclear - chemistry Ribonucleoproteins, Small Nuclear - metabolism Ribonucleoproteins, Small Nucleolar - chemistry Ribonucleoproteins, Small Nucleolar - metabolism RNA, Fungal - metabolism Saccharomyces cerevisiae - chemistry Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Structural Biology
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