Accelerated and Progressive and Lethal Liver Fibrosis in Mice That Lack Interleukin (IL)-10, IL-12p40, and IL-13Rα2

Background & Aims Progressive fibrosis contributes to the morbidity of several chronic diseases; it typically develops slowly, so the mechanisms that control its progression and resolution have been difficult to model. The proteins interleukin (IL)-10, IL-12p40, and IL-13Rα2 regulate hepatic fib...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2011-12, Vol.141 (6), p.2200-2209
Hauptverfasser:	Mentink–Kane, Margaret M, Cheever, Allen W, Wilson, Mark S, Madala, Satish K, Beers, Lara Megan, Ramalingam, Thirumalai R, Wynn, Thomas A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Disease Progression Female Gastroenterology and Hepatology Hypertension, Portal - immunology Immune Regulation Inflammation - immunology Interleukin-10 - deficiency Interleukin-10 - genetics Interleukin-10 - physiology Interleukin-12 Subunit p40 - deficiency Interleukin-12 Subunit p40 - genetics Interleukin-12 Subunit p40 - physiology Interleukin-13 Receptor alpha2 Subunit - deficiency Interleukin-13 Receptor alpha2 Subunit - genetics Interleukin-13 Receptor alpha2 Subunit - physiology Liver Cirrhosis - immunology Liver Cirrhosis - mortality Liver Cirrhosis - parasitology Mice Mice, Inbred BALB C Mice, Knockout Mouse Model Occult Blood Real-Time Polymerase Chain Reaction Schistosomiasis mansoni - immunology Schistosomiasis mansoni - mortality Schistosomiasis mansoni - parasitology T-Cell Response Th2 Response
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